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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIWIL4
All Species:
22.73
Human Site:
S451
Identified Species:
41.67
UniProt:
Q7Z3Z4
Number Species:
12
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z3Z4
NP_689644.2
852
96589
S451
L
T
G
R
I
V
P
S
E
K
I
L
M
Q
D
Chimpanzee
Pan troglodytes
XP_508702
852
96725
S451
L
T
G
R
I
V
P
S
E
K
I
L
M
Q
D
Rhesus Macaque
Macaca mulatta
XP_001089264
852
96294
S451
L
T
G
R
V
V
P
S
E
K
I
L
M
Q
D
Dog
Lupus familis
XP_542241
929
105208
S528
L
T
G
R
V
L
P
S
E
K
I
L
M
Q
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGT6
848
95755
S446
L
T
G
R
V
V
P
S
E
K
I
L
L
Q
D
Rat
Rattus norvegicus
Q4G033
848
95953
S446
L
T
G
R
V
V
P
S
E
K
I
L
L
Q
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509070
1180
134396
E779
S
G
R
I
M
Q
T
E
K
I
I
Q
S
G
K
Chicken
Gallus gallus
A6N7Y9
867
99268
E466
T
G
R
V
V
Q
A
E
K
I
L
Q
A
G
N
Frog
Xenopus laevis
Q6DCX2
862
97626
A460
V
W
A
I
A
C
F
A
P
Q
R
Q
C
T
E
Zebra Danio
Brachydanio rerio
Q8UVX0
858
97433
E457
N
G
R
V
L
P
S
E
R
I
I
Q
G
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKM1
843
97159
N447
Q
Q
N
I
V
F
H
N
G
K
V
P
A
G
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999765
854
96704
E451
T
G
R
V
L
P
P
E
K
L
F
Q
R
G
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
L558
G
I
K
I
S
T
S
L
A
S
V
E
A
R
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.6
75.3
N.A.
77.6
76.8
N.A.
38.3
48.6
21.6
47.4
N.A.
33.7
N.A.
N.A.
40.1
Protein Similarity:
100
99.8
99.3
83.6
N.A.
88.1
86.7
N.A.
52.1
67.8
43
67.1
N.A.
53.8
N.A.
N.A.
59.3
P-Site Identity:
100
100
93.3
86.6
N.A.
86.6
86.6
N.A.
6.6
0
0
6.6
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
26.6
26.6
13.3
N.A.
33.3
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
8
0
8
8
8
0
0
0
24
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
47
% D
% Glu:
0
0
0
0
0
0
0
31
47
0
0
8
0
0
16
% E
% Phe:
0
0
0
0
0
8
8
0
0
0
8
0
0
0
0
% F
% Gly:
8
31
47
0
0
0
0
0
8
0
0
0
8
39
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
31
16
0
0
0
0
24
62
0
0
0
8
% I
% Lys:
0
0
8
0
0
0
0
0
24
54
0
0
0
0
16
% K
% Leu:
47
0
0
0
16
8
0
8
0
8
8
47
16
0
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
31
0
0
% M
% Asn:
8
0
8
0
0
0
0
8
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
16
54
0
8
0
0
8
0
0
0
% P
% Gln:
8
8
0
0
0
16
0
0
0
8
0
39
0
47
0
% Q
% Arg:
0
0
31
47
0
0
0
0
8
0
8
0
8
8
8
% R
% Ser:
8
0
0
0
8
0
16
47
0
8
0
0
8
0
0
% S
% Thr:
16
47
0
0
0
8
8
0
0
0
0
0
0
8
0
% T
% Val:
8
0
0
24
47
39
0
0
0
0
16
0
0
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _