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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIWIL4
All Species:
12.12
Human Site:
S61
Identified Species:
22.22
UniProt:
Q7Z3Z4
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z3Z4
NP_689644.2
852
96589
S61
T
N
D
K
Y
G
I
S
S
G
D
A
G
S
T
Chimpanzee
Pan troglodytes
XP_508702
852
96725
S61
T
N
D
K
Y
G
I
S
S
G
D
A
G
S
T
Rhesus Macaque
Macaca mulatta
XP_001089264
852
96294
S61
T
N
D
K
Y
G
I
S
S
G
D
A
G
S
T
Dog
Lupus familis
XP_542241
929
105208
S138
Q
Q
R
E
D
G
I
S
S
G
D
A
G
C
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGT6
848
95755
G61
G
V
S
S
G
D
G
G
R
T
F
M
E
R
R
Rat
Rattus norvegicus
Q4G033
848
95953
R61
G
V
S
S
G
D
G
R
R
T
L
V
E
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509070
1180
134396
I322
Y
Y
A
P
N
T
I
I
N
T
G
A
D
S
R
Chicken
Gallus gallus
A6N7Y9
867
99268
Q61
E
P
G
G
R
G
R
Q
R
G
P
Q
D
A
P
Frog
Xenopus laevis
Q6DCX2
862
97626
C68
I
D
I
K
P
E
K
C
P
R
R
V
N
R
E
Zebra Danio
Brachydanio rerio
Q8UVX0
858
97433
L63
A
M
S
E
E
A
M
L
Q
I
S
A
G
F
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKM1
843
97159
R61
R
A
L
E
E
A
P
R
R
E
G
G
P
T
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999765
854
96704
A63
T
S
Q
I
A
K
L
A
I
G
A
S
G
E
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
L149
Q
V
P
E
P
T
V
L
A
Q
Q
F
E
Q
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.6
75.3
N.A.
77.6
76.8
N.A.
38.3
48.6
21.6
47.4
N.A.
33.7
N.A.
N.A.
40.1
Protein Similarity:
100
99.8
99.3
83.6
N.A.
88.1
86.7
N.A.
52.1
67.8
43
67.1
N.A.
53.8
N.A.
N.A.
59.3
P-Site Identity:
100
100
100
60
N.A.
0
0
N.A.
20
13.3
6.6
13.3
N.A.
0
N.A.
N.A.
20
P-Site Similarity:
100
100
100
66.6
N.A.
0
0
N.A.
26.6
20
13.3
26.6
N.A.
13.3
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
0
8
16
0
8
8
0
8
47
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% C
% Asp:
0
8
24
0
8
16
0
0
0
0
31
0
16
0
0
% D
% Glu:
8
0
0
31
16
8
0
0
0
8
0
0
24
8
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
8
0
8
0
% F
% Gly:
16
0
8
8
16
39
16
8
0
47
16
8
47
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
8
8
0
0
39
8
8
8
0
0
0
0
0
% I
% Lys:
0
0
0
31
0
8
8
0
0
0
0
0
0
8
0
% K
% Leu:
0
0
8
0
0
0
8
16
0
0
8
0
0
0
8
% L
% Met:
0
8
0
0
0
0
8
0
0
0
0
8
0
0
0
% M
% Asn:
0
24
0
0
8
0
0
0
8
0
0
0
8
0
0
% N
% Pro:
0
8
8
8
16
0
8
0
8
0
8
0
8
0
8
% P
% Gln:
16
8
8
0
0
0
0
8
8
8
8
8
0
8
8
% Q
% Arg:
8
0
8
0
8
0
8
16
31
8
8
0
0
16
24
% R
% Ser:
0
8
24
16
0
0
0
31
31
0
8
8
0
31
0
% S
% Thr:
31
0
0
0
0
16
0
0
0
24
0
0
0
8
31
% T
% Val:
0
24
0
0
0
0
8
0
0
0
0
16
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
8
0
0
24
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _