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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIWIL4
All Species:
34.85
Human Site:
T310
Identified Species:
63.89
UniProt:
Q7Z3Z4
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z3Z4
NP_689644.2
852
96589
T310
L
T
R
Y
N
N
R
T
Y
S
I
D
D
I
D
Chimpanzee
Pan troglodytes
XP_508702
852
96725
T310
L
T
R
Y
N
N
R
T
Y
S
I
D
D
I
D
Rhesus Macaque
Macaca mulatta
XP_001089264
852
96294
T310
L
T
R
Y
N
N
R
T
Y
S
I
D
D
I
D
Dog
Lupus familis
XP_542241
929
105208
T387
L
T
R
Y
N
N
K
T
Y
R
I
D
D
I
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CGT6
848
95755
T305
L
T
R
Y
N
N
K
T
Y
R
I
D
D
I
D
Rat
Rattus norvegicus
Q4G033
848
95953
T305
L
T
R
Y
N
N
K
T
Y
R
I
D
D
I
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509070
1180
134396
T635
L
T
K
Y
N
N
K
T
Y
R
V
D
D
I
D
Chicken
Gallus gallus
A6N7Y9
867
99268
T324
L
T
K
Y
N
N
R
T
Y
R
V
D
D
I
D
Frog
Xenopus laevis
Q6DCX2
862
97626
K320
Q
Y
F
K
D
R
H
K
L
V
L
R
Y
P
H
Zebra Danio
Brachydanio rerio
Q8UVX0
858
97433
T314
L
T
K
Y
N
N
K
T
Y
R
I
D
D
I
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKM1
843
97159
G308
R
I
N
D
V
D
F
G
Q
T
P
K
S
T
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999765
854
96704
Y311
T
K
Y
N
N
K
T
Y
R
V
D
D
I
D
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
K413
L
S
D
A
D
R
V
K
I
K
K
A
L
R
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.6
75.3
N.A.
77.6
76.8
N.A.
38.3
48.6
21.6
47.4
N.A.
33.7
N.A.
N.A.
40.1
Protein Similarity:
100
99.8
99.3
83.6
N.A.
88.1
86.7
N.A.
52.1
67.8
43
67.1
N.A.
53.8
N.A.
N.A.
59.3
P-Site Identity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
73.3
80
0
73.3
N.A.
0
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
13.3
86.6
N.A.
13.3
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
16
8
0
0
0
0
8
77
70
8
62
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
16
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% H
% Ile:
0
8
0
0
0
0
0
0
8
0
54
0
8
70
0
% I
% Lys:
0
8
24
8
0
8
39
16
0
8
8
8
0
0
0
% K
% Leu:
77
0
0
0
0
0
0
0
8
0
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
77
70
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% P
% Gln:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
8
0
47
0
0
16
31
0
8
47
0
8
0
8
0
% R
% Ser:
0
8
0
0
0
0
0
0
0
24
0
0
8
0
0
% S
% Thr:
8
70
0
0
0
0
8
70
0
8
0
0
0
8
0
% T
% Val:
0
0
0
0
8
0
8
0
0
16
16
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
8
70
0
0
0
8
70
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _