Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMC6 All Species: 6.36
Human Site: S171 Identified Species: 15.56
UniProt: Q7Z403 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7Z403 NP_001120670.1 805 90045 S171 M L R G M P L S L A E K R S L
Chimpanzee Pan troglodytes XP_001153587 647 75381 G80 Q K T L K I I G G K F G T S V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_540460 783 87776 S173 Q V N G V S R S G A A T S A P
Cat Felis silvestris
Mouse Mus musculus Q7TN60 810 90527 S170 M V R N M P L S L G E K R C L
Rat Rattus norvegicus Q5M7W4 965 110699 Q331 R I K T I R N Q P R T M Q E K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509198 962 110947 G200 F S D H P G R G E G D L C Y P
Chicken Gallus gallus Q5YCC5 735 84359 L164 Y F S F L R F L V L L N F L M
Frog Xenopus laevis NP_001085652 725 84100 S158 I G G R F G S S V L S Y F V F
Zebra Danio Brachydanio rerio XP_689991 670 76642 R103 S L T S A R Q R L V V W Q D T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783735 885 99854 Q227 R R R N T I R Q I S G T I D T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 32.1 N.A. 76.4 N.A. 73.6 27.7 N.A. 30.1 23.8 47.8 32.4 N.A. N.A. N.A. N.A. 22.3
Protein Similarity: 100 48.2 N.A. 82.9 N.A. 81.9 43.9 N.A. 44.7 42.6 62.4 51.2 N.A. N.A. N.A. N.A. 39.2
P-Site Identity: 100 6.6 N.A. 20 N.A. 73.3 0 N.A. 0 0 6.6 13.3 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 20 N.A. 40 N.A. 80 26.6 N.A. 6.6 20 20 20 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 0 0 0 20 10 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 10 10 0 % C
% Asp: 0 0 10 0 0 0 0 0 0 0 10 0 0 20 0 % D
% Glu: 0 0 0 0 0 0 0 0 10 0 20 0 0 10 0 % E
% Phe: 10 10 0 10 10 0 10 0 0 0 10 0 20 0 10 % F
% Gly: 0 10 10 20 0 20 0 20 20 20 10 10 0 0 0 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 10 0 0 10 20 10 0 10 0 0 0 10 0 0 % I
% Lys: 0 10 10 0 10 0 0 0 0 10 0 20 0 0 10 % K
% Leu: 0 20 0 10 10 0 20 10 30 20 10 10 0 10 20 % L
% Met: 20 0 0 0 20 0 0 0 0 0 0 10 0 0 10 % M
% Asn: 0 0 10 20 0 0 10 0 0 0 0 10 0 0 0 % N
% Pro: 0 0 0 0 10 20 0 0 10 0 0 0 0 0 20 % P
% Gln: 20 0 0 0 0 0 10 20 0 0 0 0 20 0 0 % Q
% Arg: 20 10 30 10 0 30 30 10 0 10 0 0 20 0 0 % R
% Ser: 10 10 10 10 0 10 10 40 0 10 10 0 10 20 0 % S
% Thr: 0 0 20 10 10 0 0 0 0 0 10 20 10 0 20 % T
% Val: 0 20 0 0 10 0 0 0 20 10 10 0 0 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 0 0 0 0 10 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _