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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC6
All Species:
6.06
Human Site:
S182
Identified Species:
14.81
UniProt:
Q7Z403
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z403
NP_001120670.1
805
90045
S182
K
R
S
L
R
E
K
S
R
T
P
R
G
K
W
Chimpanzee
Pan troglodytes
XP_001153587
647
75381
F91
G
T
S
V
L
S
Y
F
N
F
L
R
W
L
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_540460
783
87776
S184
T
S
A
P
R
E
E
S
R
T
L
T
R
K
R
Cat
Felis silvestris
Mouse
Mus musculus
Q7TN60
810
90527
S181
K
R
C
L
R
E
K
S
W
S
P
K
G
K
R
Rat
Rattus norvegicus
Q5M7W4
965
110699
R342
M
Q
E
K
R
E
L
R
K
I
V
D
K
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509198
962
110947
P211
L
C
Y
P
E
S
I
P
M
T
E
I
P
P
S
Chicken
Gallus gallus
Q5YCC5
735
84359
M175
N
F
L
M
F
I
L
M
F
S
F
V
T
L
P
Frog
Xenopus laevis
NP_001085652
725
84100
L169
Y
F
V
F
L
K
T
L
L
E
F
N
I
F
L
Zebra Danio
Brachydanio rerio
XP_689991
670
76642
I114
W
Q
D
T
L
K
E
I
G
G
R
F
G
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783735
885
99854
V238
T
I
D
T
R
R
R
V
R
E
Q
V
N
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32.1
N.A.
76.4
N.A.
73.6
27.7
N.A.
30.1
23.8
47.8
32.4
N.A.
N.A.
N.A.
N.A.
22.3
Protein Similarity:
100
48.2
N.A.
82.9
N.A.
81.9
43.9
N.A.
44.7
42.6
62.4
51.2
N.A.
N.A.
N.A.
N.A.
39.2
P-Site Identity:
100
13.3
N.A.
40
N.A.
66.6
13.3
N.A.
6.6
0
0
6.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
20
N.A.
53.3
N.A.
80
33.3
N.A.
6.6
13.3
6.6
26.6
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
10
10
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
20
0
0
0
0
0
0
0
0
10
0
0
0
% D
% Glu:
0
0
10
0
10
40
20
0
0
20
10
0
0
10
0
% E
% Phe:
0
20
0
10
10
0
0
10
10
10
20
10
0
10
0
% F
% Gly:
10
0
0
0
0
0
0
0
10
10
0
0
30
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
0
0
10
10
10
0
10
0
10
10
0
0
% I
% Lys:
20
0
0
10
0
20
20
0
10
0
0
10
10
30
10
% K
% Leu:
10
0
10
20
30
0
20
10
10
0
20
0
0
20
20
% L
% Met:
10
0
0
10
0
0
0
10
10
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
10
0
0
10
10
0
0
% N
% Pro:
0
0
0
20
0
0
0
10
0
0
20
0
10
10
10
% P
% Gln:
0
20
0
0
0
0
0
0
0
0
10
0
0
0
0
% Q
% Arg:
0
20
0
0
50
10
10
10
30
0
10
20
10
10
30
% R
% Ser:
0
10
20
0
0
20
0
30
0
20
0
0
0
0
20
% S
% Thr:
20
10
0
20
0
0
10
0
0
30
0
10
10
10
0
% T
% Val:
0
0
10
10
0
0
0
10
0
0
10
20
0
0
0
% V
% Trp:
10
0
0
0
0
0
0
0
10
0
0
0
10
0
10
% W
% Tyr:
10
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _