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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC6
All Species:
9.7
Human Site:
S369
Identified Species:
23.7
UniProt:
Q7Z403
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z403
NP_001120670.1
805
90045
S369
M
A
H
S
F
G
E
S
Y
R
V
G
S
T
S
Chimpanzee
Pan troglodytes
XP_001153587
647
75381
S258
N
Q
L
L
T
R
F
S
A
Y
M
V
A
W
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_540460
783
87776
S372
M
S
H
S
F
G
E
S
Y
R
V
G
S
T
A
Cat
Felis silvestris
Mouse
Mus musculus
Q7TN60
810
90527
S368
M
S
H
S
F
G
E
S
Y
R
V
G
S
T
K
Rat
Rattus norvegicus
Q5M7W4
965
110699
N513
M
A
K
Y
F
R
N
N
F
I
N
P
H
I
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509198
962
110947
N382
M
A
K
S
F
R
N
N
F
I
N
P
Y
S
Y
Chicken
Gallus gallus
Q5YCC5
735
84359
I342
E
E
R
L
K
Q
K
I
A
E
R
T
M
K
E
Frog
Xenopus laevis
NP_001085652
725
84100
L336
L
Q
S
D
R
P
T
L
L
K
K
Q
L
K
G
Zebra Danio
Brachydanio rerio
XP_689991
670
76642
N281
S
E
R
L
Q
M
K
N
K
I
S
L
S
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783735
885
99854
A408
I
A
Q
G
M
S
R
A
Y
R
Q
Y
F
V
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32.1
N.A.
76.4
N.A.
73.6
27.7
N.A.
30.1
23.8
47.8
32.4
N.A.
N.A.
N.A.
N.A.
22.3
Protein Similarity:
100
48.2
N.A.
82.9
N.A.
81.9
43.9
N.A.
44.7
42.6
62.4
51.2
N.A.
N.A.
N.A.
N.A.
39.2
P-Site Identity:
100
6.6
N.A.
86.6
N.A.
86.6
20
N.A.
26.6
0
0
6.6
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
20
N.A.
100
N.A.
93.3
33.3
N.A.
46.6
6.6
13.3
20
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
40
0
0
0
0
0
10
20
0
0
0
10
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
0
0
0
0
0
0
0
0
10
0
% D
% Glu:
10
20
0
0
0
0
30
0
0
10
0
0
0
0
10
% E
% Phe:
0
0
0
0
50
0
10
0
20
0
0
0
10
0
0
% F
% Gly:
0
0
0
10
0
30
0
0
0
0
0
30
0
0
10
% G
% His:
0
0
30
0
0
0
0
0
0
0
0
0
10
0
0
% H
% Ile:
10
0
0
0
0
0
0
10
0
30
0
0
0
10
0
% I
% Lys:
0
0
20
0
10
0
20
0
10
10
10
0
0
20
10
% K
% Leu:
10
0
10
30
0
0
0
10
10
0
0
10
10
0
0
% L
% Met:
50
0
0
0
10
10
0
0
0
0
10
0
10
0
0
% M
% Asn:
10
0
0
0
0
0
20
30
0
0
20
0
0
0
0
% N
% Pro:
0
0
0
0
0
10
0
0
0
0
0
20
0
0
0
% P
% Gln:
0
20
10
0
10
10
0
0
0
0
10
10
0
0
0
% Q
% Arg:
0
0
20
0
10
30
10
0
0
40
10
0
0
0
10
% R
% Ser:
10
20
10
40
0
10
0
40
0
0
10
0
40
10
10
% S
% Thr:
0
0
0
0
10
0
10
0
0
0
0
10
0
30
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
30
10
0
10
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% W
% Tyr:
0
0
0
10
0
0
0
0
40
10
0
10
10
0
20
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _