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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMC6 All Species: 11.21
Human Site: S374 Identified Species: 27.41
UniProt: Q7Z403 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7Z403 NP_001120670.1 805 90045 S374 G E S Y R V G S T S G I H A I
Chimpanzee Pan troglodytes XP_001153587 647 75381 A263 R F S A Y M V A W V V S T G V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_540460 783 87776 S377 G E S Y R V G S T A G V H A V
Cat Felis silvestris
Mouse Mus musculus Q7TN60 810 90527 S373 G E S Y R V G S T K G I H A L
Rat Rattus norvegicus Q5M7W4 965 110699 H518 R N N F I N P H I Y S R G I A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509198 962 110947 Y387 R N N F I N P Y S Y T R G A S
Chicken Gallus gallus Q5YCC5 735 84359 M347 Q K I A E R T M K E K L Q I Y
Frog Xenopus laevis NP_001085652 725 84100 L341 P T L L K K Q L K G L F I L M
Zebra Danio Brachydanio rerio XP_689991 670 76642 S286 M K N K I S L S D R I K H L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783735 885 99854 F413 S R A Y R Q Y F V T G D R H Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 32.1 N.A. 76.4 N.A. 73.6 27.7 N.A. 30.1 23.8 47.8 32.4 N.A. N.A. N.A. N.A. 22.3
Protein Similarity: 100 48.2 N.A. 82.9 N.A. 81.9 43.9 N.A. 44.7 42.6 62.4 51.2 N.A. N.A. N.A. N.A. 39.2
P-Site Identity: 100 6.6 N.A. 80 N.A. 86.6 0 N.A. 6.6 0 0 13.3 N.A. N.A. N.A. N.A. 20
P-Site Similarity: 100 26.6 N.A. 100 N.A. 93.3 13.3 N.A. 26.6 13.3 13.3 26.6 N.A. N.A. N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 20 0 0 0 10 0 10 0 0 0 40 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 10 0 0 10 0 0 0 % D
% Glu: 0 30 0 0 10 0 0 0 0 10 0 0 0 0 0 % E
% Phe: 0 10 0 20 0 0 0 10 0 0 0 10 0 0 0 % F
% Gly: 30 0 0 0 0 0 30 0 0 10 40 0 20 10 0 % G
% His: 0 0 0 0 0 0 0 10 0 0 0 0 40 10 0 % H
% Ile: 0 0 10 0 30 0 0 0 10 0 10 20 10 20 10 % I
% Lys: 0 20 0 10 10 10 0 0 20 10 10 10 0 0 0 % K
% Leu: 0 0 10 10 0 0 10 10 0 0 10 10 0 20 10 % L
% Met: 10 0 0 0 0 10 0 10 0 0 0 0 0 0 10 % M
% Asn: 0 20 30 0 0 20 0 0 0 0 0 0 0 0 0 % N
% Pro: 10 0 0 0 0 0 20 0 0 0 0 0 0 0 0 % P
% Gln: 10 0 0 0 0 10 10 0 0 0 0 0 10 0 0 % Q
% Arg: 30 10 0 0 40 10 0 0 0 10 0 20 10 0 0 % R
% Ser: 10 0 40 0 0 10 0 40 10 10 10 10 0 0 20 % S
% Thr: 0 10 0 0 0 0 10 0 30 10 10 0 10 0 0 % T
% Val: 0 0 0 0 0 30 10 0 10 10 10 10 0 0 20 % V
% Trp: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % W
% Tyr: 0 0 0 40 10 0 10 10 0 20 0 0 0 0 20 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _