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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC6
All Species:
10.61
Human Site:
S423
Identified Species:
25.93
UniProt:
Q7Z403
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z403
NP_001120670.1
805
90045
S423
Q
L
R
H
S
P
R
S
V
C
G
R
L
R
Q
Chimpanzee
Pan troglodytes
XP_001153587
647
75381
V312
V
S
C
I
N
L
A
V
P
C
I
Y
S
T
F
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_540460
783
87776
S426
Q
L
R
Q
V
P
R
S
L
C
G
R
L
R
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q7TN60
810
90527
S422
H
L
R
K
R
P
R
S
V
C
G
Q
L
R
Q
Rat
Rattus norvegicus
Q5M7W4
965
110699
T567
R
Q
E
N
D
R
L
T
L
N
Q
K
L
T
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509198
962
110947
P436
L
Q
D
R
V
K
L
P
L
K
K
R
M
V
Q
Chicken
Gallus gallus
Q5YCC5
735
84359
I396
S
I
R
R
N
V
M
I
A
N
L
L
V
Q
Y
Frog
Xenopus laevis
NP_001085652
725
84100
A390
G
G
E
P
E
V
E
A
M
L
L
P
L
P
L
Zebra Danio
Brachydanio rerio
XP_689991
670
76642
E335
D
P
N
D
L
V
S
E
A
S
T
L
L
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783735
885
99854
S462
A
L
T
S
H
H
S
S
D
S
I
G
C
C
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32.1
N.A.
76.4
N.A.
73.6
27.7
N.A.
30.1
23.8
47.8
32.4
N.A.
N.A.
N.A.
N.A.
22.3
Protein Similarity:
100
48.2
N.A.
82.9
N.A.
81.9
43.9
N.A.
44.7
42.6
62.4
51.2
N.A.
N.A.
N.A.
N.A.
39.2
P-Site Identity:
100
6.6
N.A.
80
N.A.
73.3
6.6
N.A.
13.3
6.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
13.3
N.A.
86.6
N.A.
80
46.6
N.A.
26.6
33.3
20
6.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
10
10
20
0
0
0
0
0
0
% A
% Cys:
0
0
10
0
0
0
0
0
0
40
0
0
10
10
0
% C
% Asp:
10
0
10
10
10
0
0
0
10
0
0
0
0
0
0
% D
% Glu:
0
0
20
0
10
0
10
10
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% F
% Gly:
10
10
0
0
0
0
0
0
0
0
30
10
0
0
0
% G
% His:
10
0
0
10
10
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
10
0
0
0
10
0
0
20
0
0
0
0
% I
% Lys:
0
0
0
10
0
10
0
0
0
10
10
10
0
0
10
% K
% Leu:
10
40
0
0
10
10
20
0
30
10
20
20
60
10
10
% L
% Met:
0
0
0
0
0
0
10
0
10
0
0
0
10
0
0
% M
% Asn:
0
0
10
10
20
0
0
0
0
20
0
0
0
0
0
% N
% Pro:
0
10
0
10
0
30
0
10
10
0
0
10
0
10
10
% P
% Gln:
20
20
0
10
0
0
0
0
0
0
10
10
0
10
40
% Q
% Arg:
10
0
40
20
10
10
30
0
0
0
0
30
0
30
10
% R
% Ser:
10
10
0
10
10
0
20
40
0
20
0
0
10
0
0
% S
% Thr:
0
0
10
0
0
0
0
10
0
0
10
0
0
20
0
% T
% Val:
10
0
0
0
20
30
0
10
20
0
0
0
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _