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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC6
All Species:
11.21
Human Site:
S646
Identified Species:
27.41
UniProt:
Q7Z403
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z403
NP_001120670.1
805
90045
S646
P
R
R
P
W
L
A
S
H
M
S
T
V
F
L
Chimpanzee
Pan troglodytes
XP_001153587
647
75381
R499
T
L
A
I
T
I
W
R
L
K
P
S
A
D
C
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_540460
783
87776
K631
L
C
L
F
Y
I
K
K
T
S
L
M
A
N
C
Cat
Felis silvestris
Mouse
Mus musculus
Q7TN60
810
90527
S645
P
R
R
P
W
L
A
S
H
M
S
T
V
F
L
Rat
Rattus norvegicus
Q5M7W4
965
110699
S789
P
S
K
A
W
R
A
S
Q
M
I
T
F
F
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509198
962
110947
S658
P
R
K
V
W
R
A
S
Q
M
M
T
L
F
I
Chicken
Gallus gallus
Q5YCC5
735
84359
S584
I
H
T
R
K
P
A
S
R
P
I
R
A
S
S
Frog
Xenopus laevis
NP_001085652
725
84100
C577
T
A
F
L
T
L
L
C
F
P
S
F
L
G
A
Zebra Danio
Brachydanio rerio
XP_689991
670
76642
F522
V
F
I
A
L
L
F
F
P
S
F
V
G
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783735
885
99854
G662
S
L
R
P
W
K
A
G
L
A
K
T
V
F
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32.1
N.A.
76.4
N.A.
73.6
27.7
N.A.
30.1
23.8
47.8
32.4
N.A.
N.A.
N.A.
N.A.
22.3
Protein Similarity:
100
48.2
N.A.
82.9
N.A.
81.9
43.9
N.A.
44.7
42.6
62.4
51.2
N.A.
N.A.
N.A.
N.A.
39.2
P-Site Identity:
100
0
N.A.
0
N.A.
100
46.6
N.A.
53.3
13.3
13.3
13.3
N.A.
N.A.
N.A.
N.A.
53.3
P-Site Similarity:
100
13.3
N.A.
13.3
N.A.
100
60
N.A.
73.3
13.3
20
13.3
N.A.
N.A.
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
20
0
0
60
0
0
10
0
0
30
10
10
% A
% Cys:
0
10
0
0
0
0
0
10
0
0
0
0
0
0
20
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
10
10
10
0
0
10
10
10
0
10
10
10
50
0
% F
% Gly:
0
0
0
0
0
0
0
10
0
0
0
0
10
10
0
% G
% His:
0
10
0
0
0
0
0
0
20
0
0
0
0
0
0
% H
% Ile:
10
0
10
10
0
20
0
0
0
0
20
0
0
0
20
% I
% Lys:
0
0
20
0
10
10
10
10
0
10
10
0
0
0
0
% K
% Leu:
10
20
10
10
10
40
10
0
20
0
10
0
20
0
40
% L
% Met:
0
0
0
0
0
0
0
0
0
40
10
10
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% N
% Pro:
40
0
0
30
0
10
0
0
10
20
10
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
20
0
0
0
0
0
0
% Q
% Arg:
0
30
30
10
0
20
0
10
10
0
0
10
0
0
0
% R
% Ser:
10
10
0
0
0
0
0
50
0
20
30
10
0
10
10
% S
% Thr:
20
0
10
0
20
0
0
0
10
0
0
50
0
0
0
% T
% Val:
10
0
0
10
0
0
0
0
0
0
0
10
30
0
0
% V
% Trp:
0
0
0
0
50
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _