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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMC6 All Species: 3.94
Human Site: T78 Identified Species: 9.63
UniProt: Q7Z403 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7Z403 NP_001120670.1 805 90045 T78 E G T Q S T A T L R I L A S M
Chimpanzee Pan troglodytes XP_001153587 647 75381
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_540460 783 87776 V78 L G P E D P L V H S T A T L R
Cat Felis silvestris
Mouse Mus musculus Q7TN60 810 90527 T77 A P A L S S A T L R I L A S M
Rat Rattus norvegicus Q5M7W4 965 110699 P95 C H P R S A H P R T R P D Y E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509198 962 110947 S106 D Y P D Y P G S R D Y P D Y P
Chicken Gallus gallus Q5YCC5 735 84359 R72 R G I A S A E R R E P Q P D G
Frog Xenopus laevis NP_001085652 725 84100 L66 A Q E E Q Q R L L V S E L Q T
Zebra Danio Brachydanio rerio XP_689991 670 76642 G11 M S V Y P Q H G T A L E N L G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783735 885 99854 G101 S G Q T P L M G R S R S P S V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 32.1 N.A. 76.4 N.A. 73.6 27.7 N.A. 30.1 23.8 47.8 32.4 N.A. N.A. N.A. N.A. 22.3
Protein Similarity: 100 48.2 N.A. 82.9 N.A. 81.9 43.9 N.A. 44.7 42.6 62.4 51.2 N.A. N.A. N.A. N.A. 39.2
P-Site Identity: 100 0 N.A. 6.6 N.A. 66.6 6.6 N.A. 0 13.3 6.6 0 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 0 N.A. 13.3 N.A. 73.3 13.3 N.A. 13.3 13.3 13.3 6.6 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 0 10 10 0 20 20 0 0 10 0 10 20 0 0 % A
% Cys: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 10 10 0 0 0 0 10 0 0 20 10 0 % D
% Glu: 10 0 10 20 0 0 10 0 0 10 0 20 0 0 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 40 0 0 0 0 10 20 0 0 0 0 0 0 20 % G
% His: 0 10 0 0 0 0 20 0 10 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 0 20 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 0 0 10 0 10 10 10 30 0 10 20 10 20 0 % L
% Met: 10 0 0 0 0 0 10 0 0 0 0 0 0 0 20 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % N
% Pro: 0 10 30 0 20 20 0 10 0 0 10 20 20 0 10 % P
% Gln: 0 10 10 10 10 20 0 0 0 0 0 10 0 10 0 % Q
% Arg: 10 0 0 10 0 0 10 10 40 20 20 0 0 0 10 % R
% Ser: 10 10 0 0 40 10 0 10 0 20 10 10 0 30 0 % S
% Thr: 0 0 10 10 0 10 0 20 10 10 10 0 10 0 10 % T
% Val: 0 0 10 0 0 0 0 10 0 10 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 10 10 0 0 0 0 0 10 0 0 20 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _