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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KCNK18
All Species:
4.55
Human Site:
T216
Identified Species:
11.11
UniProt:
Q7Z418
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.56
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z418
NP_862823.1
384
43671
T216
L
P
G
P
K
L
G
T
C
P
S
R
P
S
C
Chimpanzee
Pan troglodytes
XP_521614
383
43558
T216
L
P
S
P
K
L
G
T
C
P
S
R
P
S
C
Rhesus Macaque
Macaca mulatta
XP_001095493
383
43605
K215
L
P
G
P
K
L
G
K
C
P
S
R
P
S
C
Dog
Lupus familis
XP_544037
381
43021
R213
L
P
D
V
K
P
G
R
C
P
S
A
P
G
G
Cat
Felis silvestris
Mouse
Mus musculus
Q6VV64
394
44385
K228
L
L
N
P
Q
P
S
K
D
P
P
S
P
S
C
Rat
Rattus norvegicus
Q6Q1P3
405
45333
R239
L
L
D
P
Q
P
S
R
E
P
A
S
P
S
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513320
339
38516
P173
V
S
E
E
P
A
L
P
T
S
G
R
R
H
S
Chicken
Gallus gallus
XP_001234729
358
41274
R188
L
R
S
Q
S
A
V
R
K
K
P
A
Q
Y
R
Frog
Xenopus laevis
Q63ZI0
374
42700
Y190
E
W
S
F
F
Q
A
Y
Y
Y
C
F
I
T
L
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001022681
372
42061
L194
R
L
K
F
R
L
I
L
W
H
K
K
R
K
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.8
97.4
73.9
N.A.
64.9
65.1
N.A.
44.5
41.6
20.5
N.A.
N.A.
N.A.
N.A.
27.8
N.A.
Protein Similarity:
100
97.9
98.4
82.8
N.A.
76.9
76.5
N.A.
58.5
55.7
36.9
N.A.
N.A.
N.A.
N.A.
48.1
N.A.
P-Site Identity:
100
93.3
93.3
53.3
N.A.
40
40
N.A.
6.6
6.6
0
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
93.3
93.3
53.3
N.A.
46.6
53.3
N.A.
13.3
6.6
6.6
N.A.
N.A.
N.A.
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
20
10
0
0
0
10
20
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
40
0
10
0
0
0
50
% C
% Asp:
0
0
20
0
0
0
0
0
10
0
0
0
0
0
0
% D
% Glu:
10
0
10
10
0
0
0
0
10
0
0
0
0
0
0
% E
% Phe:
0
0
0
20
10
0
0
0
0
0
0
10
0
0
0
% F
% Gly:
0
0
20
0
0
0
40
0
0
0
10
0
0
10
10
% G
% His:
0
0
0
0
0
0
0
0
0
10
0
0
0
10
0
% H
% Ile:
0
0
0
0
0
0
10
0
0
0
0
0
10
0
0
% I
% Lys:
0
0
10
0
40
0
0
20
10
10
10
10
0
10
0
% K
% Leu:
70
30
0
0
0
40
10
10
0
0
0
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
40
0
50
10
30
0
10
0
60
20
0
60
0
0
% P
% Gln:
0
0
0
10
20
10
0
0
0
0
0
0
10
0
0
% Q
% Arg:
10
10
0
0
10
0
0
30
0
0
0
40
20
0
10
% R
% Ser:
0
10
30
0
10
0
20
0
0
10
40
20
0
50
10
% S
% Thr:
0
0
0
0
0
0
0
20
10
0
0
0
0
10
0
% T
% Val:
10
0
0
10
0
0
10
0
0
0
0
0
0
0
0
% V
% Trp:
0
10
0
0
0
0
0
0
10
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
10
10
10
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _