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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDDC2
All Species:
28.48
Human Site:
Y154
Identified Species:
52.22
UniProt:
Q7Z4H3
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z4H3
NP_057147.2
204
23390
Y154
M
I
L
Q
A
S
E
Y
E
D
L
E
H
K
P
Chimpanzee
Pan troglodytes
XP_001152848
282
31963
Y218
M
I
L
Q
A
S
E
Y
E
D
L
E
H
K
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_533487
207
23510
Y157
M
I
L
Q
A
S
E
Y
E
D
A
E
N
K
P
Cat
Felis silvestris
Mouse
Mus musculus
Q3SXD3
199
22734
Y149
M
I
L
Q
A
S
E
Y
E
D
L
E
N
K
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507226
188
21731
Y136
M
I
L
Q
A
F
E
Y
E
E
L
E
N
R
P
Chicken
Gallus gallus
Frog
Xenopus laevis
Q66L17
201
23091
Y151
M
I
L
Q
A
L
E
Y
E
E
L
E
K
R
P
Zebra Danio
Brachydanio rerio
Q1LUI2
200
22901
Y141
M
I
I
Q
A
H
E
Y
E
E
L
E
G
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609052
388
42501
Y317
M
V
M
Q
A
F
E
Y
E
K
R
D
N
C
L
Honey Bee
Apis mellifera
XP_624893
190
21983
E141
D
L
I
M
Q
A
Y
E
Y
E
K
R
D
N
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002309375
207
23067
K158
K
I
V
K
D
F
D
K
V
E
M
I
L
Q
A
Maize
Zea mays
NP_001148228
246
26685
A172
L
L
G
G
G
S
R
A
Q
E
I
R
E
L
W
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_973522
257
28363
K208
K
V
V
K
D
F
D
K
V
E
L
I
L
Q
A
Baker's Yeast
Sacchar. cerevisiae
P38331
238
27558
E188
E
M
L
V
Q
C
F
E
Y
E
R
E
Y
K
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
62.7
N.A.
79.2
N.A.
86.7
N.A.
N.A.
71.5
N.A.
71
62.2
N.A.
27.5
41.6
N.A.
N.A.
Protein Similarity:
100
65.2
N.A.
86.9
N.A.
93.6
N.A.
N.A.
83.8
N.A.
85.7
78.9
N.A.
38.9
65.1
N.A.
N.A.
P-Site Identity:
100
100
N.A.
86.6
N.A.
93.3
N.A.
N.A.
73.3
N.A.
73.3
73.3
N.A.
40
0
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
93.3
N.A.
100
N.A.
N.A.
93.3
N.A.
86.6
86.6
N.A.
66.6
26.6
N.A.
N.A.
Percent
Protein Identity:
44.9
42.6
N.A.
37.7
36.9
N.A.
Protein Similarity:
63.7
55.6
N.A.
53.7
54.6
N.A.
P-Site Identity:
6.6
6.6
N.A.
6.6
20
N.A.
P-Site Similarity:
46.6
40
N.A.
46.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
62
8
0
8
0
0
8
0
0
0
16
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% C
% Asp:
8
0
0
0
16
0
16
0
0
31
0
8
8
0
0
% D
% Glu:
8
0
0
0
0
0
62
16
62
62
0
62
8
0
0
% E
% Phe:
0
0
0
0
0
31
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
8
8
0
0
0
0
0
0
0
8
0
8
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
16
0
0
% H
% Ile:
0
62
16
0
0
0
0
0
0
0
8
16
0
0
8
% I
% Lys:
16
0
0
16
0
0
0
16
0
8
8
0
8
47
0
% K
% Leu:
8
16
54
0
0
8
0
0
0
0
54
0
16
8
8
% L
% Met:
62
8
8
8
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
31
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% P
% Gln:
0
0
0
62
16
0
0
0
8
0
0
0
0
16
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
0
16
16
0
16
0
% R
% Ser:
0
0
0
0
0
39
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
16
16
8
0
0
0
0
16
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
8
62
16
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _