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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KIF21A All Species: 4.55
Human Site: S1223 Identified Species: 9.09
UniProt: Q7Z4S6 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7Z4S6 NP_060111.2 1674 187179 S1223 G L P S K I G S I S R Q S S L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001099469 1663 184637 L1210 I T K S L A S L V E I K E D G
Dog Lupus familis XP_547366 1470 163982 A1038 D S I T D C Q A T I V Q L E E
Cat Felis silvestris
Mouse Mus musculus Q9QXL2 1672 186518 S1221 L A P S G L P S K I G S I S R
Rat Rattus norvegicus Q7M6Z5 1394 158861 L962 I V S K K E A L L Q E K S H L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521746 1544 171654 L1091 I T K S L A S L T E I K E D A
Chicken Gallus gallus Q90640 1225 138905 S793 Q L K E K K E S G E N P P S K
Frog Xenopus laevis Q91784 1226 138905 I794 K T D A G E R I P T K I R R R
Zebra Danio Brachydanio rerio Q58G59 1363 154819 E931 R W L D E E M E K V L D Q R R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_394542 1442 161348 D1010 Y G V Q A N P D N L R T E E Q
Nematode Worm Caenorhab. elegans P46873 699 78760 S267 S A L G N V I S A L V D G K S
Sea Urchin Strong. purpuratus P46871 742 84184 T310 S L G G N A K T V M V A N M G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 56.5 50 N.A. 93.7 24.9 N.A. 55.2 26.8 28.2 23.4 N.A. N.A. 43.9 22.3 22.2
Protein Similarity: 100 N.A. 72.5 64.6 N.A. 96.4 43.9 N.A. 70.8 44.6 43.4 43.1 N.A. N.A. 60.1 30.5 32.5
P-Site Identity: 100 N.A. 6.6 6.6 N.A. 26.6 20 N.A. 6.6 26.6 0 0 N.A. N.A. 6.6 6.6 6.6
P-Site Similarity: 100 N.A. 20 20 N.A. 33.3 40 N.A. 13.3 26.6 20 6.6 N.A. N.A. 6.6 13.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 0 9 9 25 9 9 9 0 0 9 0 0 9 % A
% Cys: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 0 9 9 9 0 0 9 0 0 0 17 0 17 0 % D
% Glu: 0 0 0 9 9 25 9 9 0 25 9 0 25 17 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 9 9 9 17 17 0 9 0 9 0 9 0 9 0 17 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 25 0 9 0 0 9 9 9 9 17 17 9 9 0 0 % I
% Lys: 9 0 25 9 25 9 9 0 17 0 9 25 0 9 9 % K
% Leu: 9 25 17 0 17 9 0 25 9 17 9 0 9 0 17 % L
% Met: 0 0 0 0 0 0 9 0 0 9 0 0 0 9 0 % M
% Asn: 0 0 0 0 17 9 0 0 9 0 9 0 9 0 0 % N
% Pro: 0 0 17 0 0 0 17 0 9 0 0 9 9 0 0 % P
% Gln: 9 0 0 9 0 0 9 0 0 9 0 17 9 0 9 % Q
% Arg: 9 0 0 0 0 0 9 0 0 0 17 0 9 17 25 % R
% Ser: 17 9 9 34 0 0 17 34 0 9 0 9 17 25 9 % S
% Thr: 0 25 0 9 0 0 0 9 17 9 0 9 0 0 0 % T
% Val: 0 9 9 0 0 9 0 0 17 9 25 0 0 0 0 % V
% Trp: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _