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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HUWE1
All Species:
18.18
Human Site:
Y2565
Identified Species:
50
UniProt:
Q7Z6Z7
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z6Z7
NP_113584.3
4374
481891
Y2565
G
H
T
I
H
V
H
Y
P
G
N
R
Q
P
N
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001088987
4374
481661
Y2565
G
H
T
I
H
V
H
Y
P
G
N
R
Q
P
N
Dog
Lupus familis
XP_538052
4375
482124
Y2565
G
H
T
I
H
V
H
Y
P
G
N
R
Q
P
N
Cat
Felis silvestris
Mouse
Mus musculus
Q7TMY8
4377
482644
Y2565
G
H
T
I
H
V
H
Y
P
G
N
R
Q
P
N
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001923899
4360
479137
Y2557
G
H
T
I
H
V
H
Y
P
G
N
R
Q
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573059
5146
556842
F3011
G
S
W
M
A
P
D
F
N
F
I
R
I
S
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500284
4177
465393
E2473
D
G
D
Q
N
E
H
E
A
E
E
D
D
H
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GY23
3681
404981
V2021
A
E
Q
L
K
S
E
V
P
N
E
K
K
N
R
Baker's Yeast
Sacchar. cerevisiae
Q03280
3268
374166
E1608
T
E
K
S
D
I
Y
E
R
T
G
I
M
H
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
98.7
N.A.
97.7
N.A.
N.A.
N.A.
N.A.
N.A.
81.6
N.A.
33.7
N.A.
26.2
N.A.
Protein Similarity:
100
N.A.
99.7
99.1
N.A.
98.6
N.A.
N.A.
N.A.
N.A.
N.A.
88.4
N.A.
48.4
N.A.
44.3
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
100
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
100
N.A.
26.6
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.1
38.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
0
0
12
0
0
0
12
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
0
12
0
12
0
12
0
0
0
0
12
12
0
12
% D
% Glu:
0
23
0
0
0
12
12
23
0
12
23
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
12
0
12
0
0
0
0
0
% F
% Gly:
67
12
0
0
0
0
0
0
0
56
12
0
0
0
12
% G
% His:
0
56
0
0
56
0
67
0
0
0
0
0
0
23
0
% H
% Ile:
0
0
0
56
0
12
0
0
0
0
12
12
12
0
0
% I
% Lys:
0
0
12
0
12
0
0
0
0
0
0
12
12
0
0
% K
% Leu:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
12
% L
% Met:
0
0
0
12
0
0
0
0
0
0
0
0
12
0
0
% M
% Asn:
0
0
0
0
12
0
0
0
12
12
56
0
0
12
56
% N
% Pro:
0
0
0
0
0
12
0
0
67
0
0
0
0
56
0
% P
% Gln:
0
0
12
12
0
0
0
0
0
0
0
0
56
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
12
0
0
67
0
0
12
% R
% Ser:
0
12
0
12
0
12
0
0
0
0
0
0
0
12
0
% S
% Thr:
12
0
56
0
0
0
0
0
0
12
0
0
0
0
0
% T
% Val:
0
0
0
0
0
56
0
12
0
0
0
0
0
0
0
% V
% Trp:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
12
56
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _