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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS13B All Species: 11.21
Human Site: T2292 Identified Species: 27.41
UniProt: Q7Z7G8 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7Z7G8 NP_056058.2 4022 448734 T2292 S P V E K N Q T F K S E Q S S
Chimpanzee Pan troglodytes XP_001151119 4022 448598 T2292 S P V E E N Q T F K S E Q S S
Rhesus Macaque Macaca mulatta XP_001096361 4022 448602 T2292 S P V E K N Q T F K S E Q T S
Dog Lupus familis XP_539102 4019 448360 I2288 S P I E M N Q I F K S E Q S S
Cat Felis silvestris
Mouse Mus musculus Q80TY5 4013 445905 A2285 S P V E K T Q A F K T E Q S S
Rat Rattus norvegicus NP_001128358 3995 444676 A2266 S P M E K A Q A F K T E Q S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418354 4030 449778 A2298 S S T E R N Q A S K T E H S S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651753 3731 424969 S2133 G S E D E D L S I E Y L Q S D
Honey Bee Apis mellifera XP_396487 3682 415177 P2084 I W R V V L L P N N N R P L T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001182513 3276 360338 R1678 A S W E Q V M R S S E Q G R M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.4 90.1 N.A. 87 85.8 N.A. N.A. 79.2 N.A. N.A. N.A. 22.5 26.3 N.A. 26.8
Protein Similarity: 100 99.7 98.8 95.2 N.A. 93 92 N.A. N.A. 88.4 N.A. N.A. N.A. 42.7 46.6 N.A. 44.2
P-Site Identity: 100 93.3 93.3 80 N.A. 80 73.3 N.A. N.A. 53.3 N.A. N.A. N.A. 13.3 0 N.A. 6.6
P-Site Similarity: 100 100 100 86.6 N.A. 86.6 86.6 N.A. N.A. 66.6 N.A. N.A. N.A. 46.6 13.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 0 10 0 30 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 0 10 0 0 0 0 0 0 0 0 10 % D
% Glu: 0 0 10 80 20 0 0 0 0 10 10 70 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 60 0 0 0 0 0 0 % F
% Gly: 10 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % H
% Ile: 10 0 10 0 0 0 0 10 10 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 40 0 0 0 0 70 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 10 20 0 0 0 0 10 0 10 0 % L
% Met: 0 0 10 0 10 0 10 0 0 0 0 0 0 0 10 % M
% Asn: 0 0 0 0 0 50 0 0 10 10 10 0 0 0 0 % N
% Pro: 0 60 0 0 0 0 0 10 0 0 0 0 10 0 0 % P
% Gln: 0 0 0 0 10 0 70 0 0 0 0 10 70 0 0 % Q
% Arg: 0 0 10 0 10 0 0 10 0 0 0 10 0 10 0 % R
% Ser: 70 30 0 0 0 0 0 10 20 10 40 0 0 70 70 % S
% Thr: 0 0 10 0 0 10 0 30 0 0 30 0 0 10 10 % T
% Val: 0 0 40 10 10 10 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 10 10 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _