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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMED4
All Species:
45.76
Human Site:
T187
Identified Species:
83.89
UniProt:
Q7Z7H5
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z7H5
NP_872353.2
227
25943
T187
R
E
E
R
F
R
L
T
S
E
S
T
N
Q
R
Chimpanzee
Pan troglodytes
XP_001145929
227
26023
T187
R
E
E
R
F
R
L
T
S
E
S
T
N
Q
R
Rhesus Macaque
Macaca mulatta
XP_001091521
227
26096
T187
R
E
E
R
F
R
L
T
S
E
S
T
N
Q
R
Dog
Lupus familis
XP_532721
216
24954
T176
R
E
E
R
F
R
L
T
S
E
S
T
N
Q
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8R1V4
227
26003
T187
R
E
E
R
F
R
L
T
S
E
S
T
N
Q
R
Rat
Rattus norvegicus
Q63584
219
24839
T178
R
E
E
E
M
R
D
T
N
E
S
T
N
T
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086296
228
26479
T188
R
E
E
R
F
R
L
T
S
E
S
T
N
Q
R
Zebra Danio
Brachydanio rerio
NP_001002134
220
25556
T180
R
E
E
R
F
R
M
T
S
E
S
T
N
Q
R
Tiger Blowfish
Takifugu rubipres
Q90515
213
24635
T172
R
E
E
E
M
R
D
T
N
E
S
T
N
T
R
Fruit Fly
Dros. melanogaster
Q9I7K5
216
25140
T176
R
E
E
R
F
R
H
T
S
E
S
T
N
S
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784509
218
25564
T178
R
E
E
R
F
R
T
T
S
E
S
T
N
Q
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53198
216
25257
I176
R
E
E
S
F
R
D
I
S
E
S
V
N
S
R
Red Bread Mold
Neurospora crassa
Q9HEK4
215
24521
T175
R
E
Q
K
L
R
D
T
N
E
S
T
N
N
R
Conservation
Percent
Protein Identity:
100
99.5
98.2
91.6
N.A.
94.7
34.7
N.A.
N.A.
N.A.
83.7
81.5
31.7
65.1
N.A.
N.A.
71.3
Protein Similarity:
100
99.5
98.6
93.3
N.A.
96.4
53.7
N.A.
N.A.
N.A.
89
88.9
51.1
78.4
N.A.
N.A.
84.1
P-Site Identity:
100
100
100
100
N.A.
100
66.6
N.A.
N.A.
N.A.
100
93.3
66.6
86.6
N.A.
N.A.
93.3
P-Site Similarity:
100
100
100
100
N.A.
100
73.3
N.A.
N.A.
N.A.
100
100
73.3
86.6
N.A.
N.A.
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.5
28.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
46.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
66.6
60
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
80
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
31
0
0
0
0
0
0
0
0
% D
% Glu:
0
100
93
16
0
0
0
0
0
100
0
0
0
0
0
% E
% Phe:
0
0
0
0
77
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
8
0
47
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
16
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
24
0
0
0
100
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
0
0
62
0
% Q
% Arg:
100
0
0
70
0
100
0
0
0
0
0
0
0
0
100
% R
% Ser:
0
0
0
8
0
0
0
0
77
0
100
0
0
16
0
% S
% Thr:
0
0
0
0
0
0
8
93
0
0
0
93
0
16
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _