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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMED4
All Species:
34.55
Human Site:
Y94
Identified Species:
63.33
UniProt:
Q7Z7H5
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z7H5
NP_872353.2
227
25943
Y94
K
V
V
L
S
R
Q
Y
G
S
E
G
R
F
T
Chimpanzee
Pan troglodytes
XP_001145929
227
26023
Y94
K
V
V
L
S
R
Q
Y
G
S
E
G
R
F
T
Rhesus Macaque
Macaca mulatta
XP_001091521
227
26096
Y94
K
V
V
L
S
R
Q
Y
G
S
E
G
R
F
T
Dog
Lupus familis
XP_532721
216
24954
Y83
K
V
V
L
S
R
Q
Y
G
S
E
G
R
F
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8R1V4
227
26003
Y94
K
V
V
L
S
R
Q
Y
G
S
E
G
R
F
T
Rat
Rattus norvegicus
Q63584
219
24839
D89
H
I
L
Y
A
K
E
D
A
T
K
G
K
F
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086296
228
26479
Y95
K
V
I
L
S
R
Q
Y
G
S
E
G
R
F
T
Zebra Danio
Brachydanio rerio
NP_001002134
220
25556
Y87
K
V
I
L
S
R
Q
Y
G
S
D
G
R
F
T
Tiger Blowfish
Takifugu rubipres
Q90515
213
24635
D83
H
T
L
Y
S
K
E
D
A
T
K
G
K
F
A
Fruit Fly
Dros. melanogaster
Q9I7K5
216
25140
Y85
K
I
V
L
S
R
V
Y
S
S
Q
G
R
I
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784509
218
25564
Y85
K
M
I
L
S
K
M
Y
S
S
S
G
R
F
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53198
216
25257
G87
H
R
V
V
H
Q
Q
G
S
P
S
G
D
F
S
Red Bread Mold
Neurospora crassa
Q9HEK4
215
24521
I83
E
Y
G
K
A
K
D
I
A
G
E
Q
R
I
V
Conservation
Percent
Protein Identity:
100
99.5
98.2
91.6
N.A.
94.7
34.7
N.A.
N.A.
N.A.
83.7
81.5
31.7
65.1
N.A.
N.A.
71.3
Protein Similarity:
100
99.5
98.6
93.3
N.A.
96.4
53.7
N.A.
N.A.
N.A.
89
88.9
51.1
78.4
N.A.
N.A.
84.1
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
N.A.
N.A.
93.3
86.6
20
60
N.A.
N.A.
60
P-Site Similarity:
100
100
100
100
N.A.
100
66.6
N.A.
N.A.
N.A.
100
100
60
80
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.5
28.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
46.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
16
0
0
0
24
0
0
0
0
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
16
0
0
8
0
8
0
0
% D
% Glu:
8
0
0
0
0
0
16
0
0
0
54
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
85
0
% F
% Gly:
0
0
8
0
0
0
0
8
54
8
0
93
0
0
0
% G
% His:
24
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
16
24
0
0
0
0
8
0
0
0
0
0
16
0
% I
% Lys:
70
0
0
8
0
31
0
0
0
0
16
0
16
0
0
% K
% Leu:
0
0
16
70
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
62
0
0
0
8
8
0
0
0
% Q
% Arg:
0
8
0
0
0
62
0
0
0
0
0
0
77
0
0
% R
% Ser:
0
0
0
0
77
0
0
0
24
70
16
0
0
0
16
% S
% Thr:
0
8
0
0
0
0
0
0
0
16
0
0
0
0
62
% T
% Val:
0
54
54
8
0
0
8
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
16
0
0
0
70
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _