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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CENPV All Species: 5.15
Human Site: T245 Identified Species: 9.44
UniProt: Q7Z7K6 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7Z7K6 NP_859067.2 275 29946 T245 P H C L D E G T V R S M V T E
Chimpanzee Pan troglodytes XP_528984 287 31346 T245 P H C L D E G T V R S V V I E
Rhesus Macaque Macaca mulatta XP_001088768 164 18804 V135 H C L D E G T V R S M V T E E
Dog Lupus familis XP_546642 178 20038 V149 H C L D E G T V R S V V I E E
Cat Felis silvestris
Mouse Mus musculus Q9CXS4 252 27523 V223 H C L D E G T V R S V V T E E
Rat Rattus norvegicus XP_577104 250 27497 V221 H C L D E G T V R S V V T E E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509162 150 16910 V121 H C L D E G T V R S V V L E E
Chicken Gallus gallus XP_415846 215 23739 V186 H C L D D G T V H S I V T E D
Frog Xenopus laevis NP_001090477 235 26370 V206 H C L D E G T V R S V H V E Q
Zebra Danio Brachydanio rerio XP_002662101 151 16897 V122 G T V N S V T V E D F C G Q N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_741540 129 14558 D100 A I M P H C I D G K T L K G V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002302934 137 15355 T108 C V D P G T L T H V E I K N F
Maize Zea mays NP_001148610 142 15657 Y113 G T L K H V E Y R K F D G R N
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 47.3 52.7 61.4 N.A. 73.8 71.6 N.A. 45 57 54.1 39.2 N.A. N.A. N.A. 26.1 N.A.
Protein Similarity: 100 59.5 54.9 62.9 N.A. 78.1 77.8 N.A. 49.8 68 66.9 47.2 N.A. N.A. N.A. 33 N.A.
P-Site Identity: 100 86.6 6.6 6.6 N.A. 6.6 6.6 N.A. 6.6 6.6 6.6 0 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 93.3 20 26.6 N.A. 20 20 N.A. 26.6 20 20 0 N.A. N.A. N.A. 20 N.A.
Percent
Protein Identity: 22.1 25.8 N.A. N.A. N.A. N.A.
Protein Similarity: 30.1 33.4 N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 0 N.A. N.A. N.A. N.A.
P-Site Similarity: 13.3 6.6 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 8 54 16 0 0 8 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 0 8 54 24 0 0 8 0 8 0 8 0 0 8 % D
% Glu: 0 0 0 0 47 16 8 0 8 0 8 0 0 54 54 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 16 0 0 0 8 % F
% Gly: 16 0 0 0 8 54 16 0 8 0 0 0 16 8 0 % G
% His: 54 16 0 0 16 0 0 0 16 0 0 8 0 0 0 % H
% Ile: 0 8 0 0 0 0 8 0 0 0 8 8 8 8 0 % I
% Lys: 0 0 0 8 0 0 0 0 0 16 0 0 16 0 0 % K
% Leu: 0 0 62 16 0 0 8 0 0 0 0 8 8 0 0 % L
% Met: 0 0 8 0 0 0 0 0 0 0 8 8 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 0 0 0 0 0 0 8 16 % N
% Pro: 16 0 0 16 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 8 % Q
% Arg: 0 0 0 0 0 0 0 0 54 16 0 0 0 8 0 % R
% Ser: 0 0 0 0 8 0 0 0 0 54 16 0 0 0 0 % S
% Thr: 0 16 0 0 0 8 62 24 0 0 8 0 31 8 0 % T
% Val: 0 8 8 0 0 16 0 62 16 8 39 54 24 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _