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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ATG4D
All Species:
18.18
Human Site:
S418
Identified Species:
28.57
UniProt:
Q86TL0
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86TL0
NP_116274.3
474
52922
S418
E
L
T
R
V
L
S
S
S
S
A
T
E
R
Y
Chimpanzee
Pan troglodytes
XP_512373
411
46398
S356
L
T
R
V
L
S
S
S
S
A
T
E
R
Y
P
Rhesus Macaque
Macaca mulatta
XP_001101860
474
52893
S418
E
L
T
R
V
L
G
S
S
S
A
T
E
R
Y
Dog
Lupus familis
XP_542069
473
52729
S417
E
L
T
R
V
L
S
S
S
S
A
T
E
R
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8BGV9
474
52892
S418
E
L
M
R
I
L
S
S
S
S
V
T
E
R
Y
Rat
Rattus norvegicus
NP_001094483
473
52805
S417
E
L
M
R
I
L
S
S
S
S
V
T
E
R
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514370
459
52127
R396
R
N
V
Q
D
F
E
R
A
S
E
E
I
T
K
Chicken
Gallus gallus
Q6PZ02
393
44512
K338
D
W
C
H
Q
I
K
K
L
S
L
V
R
G
A
Frog
Xenopus laevis
Q68FJ9
469
52793
D404
F
Y
A
K
N
S
E
D
F
G
K
L
C
D
H
Zebra Danio
Brachydanio rerio
Q6DG88
394
44435
R339
D
D
W
C
A
Q
I
R
K
V
S
N
C
R
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650452
668
74736
P572
S
V
Q
L
Y
L
H
P
M
R
C
A
S
G
A
Honey Bee
Apis mellifera
XP_393739
477
54008
P420
I
A
P
S
Y
L
V
P
E
D
E
K
I
D
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786847
723
81931
P662
E
L
P
T
V
V
S
P
L
G
S
H
S
S
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8S929
467
51510
V381
V
N
K
E
T
P
D
V
D
T
S
S
Y
H
C
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7S3X7
506
55337
D451
G
F
L
I
K
D
E
D
D
W
D
T
W
K
S
Conservation
Percent
Protein Identity:
100
84.8
98.5
94.3
N.A.
86.2
86.7
N.A.
44
26.5
53.3
27
N.A.
30.3
35
N.A.
30.8
Protein Similarity:
100
85.6
98.9
96.1
N.A.
90.9
91.1
N.A.
59.4
39.6
68.9
41.9
N.A.
44.4
49.2
N.A.
41.9
P-Site Identity:
100
20
93.3
100
N.A.
80
80
N.A.
6.6
6.6
0
6.6
N.A.
6.6
13.3
N.A.
26.6
P-Site Similarity:
100
33.3
93.3
100
N.A.
86.6
86.6
N.A.
20
20
13.3
20
N.A.
13.3
13.3
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.4
N.A.
22.1
Protein Similarity:
N.A.
N.A.
N.A.
42.4
N.A.
36.3
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
7
0
0
0
7
7
20
7
0
0
14
% A
% Cys:
0
0
7
7
0
0
0
0
0
0
7
0
14
0
7
% C
% Asp:
14
7
0
0
7
7
7
14
14
7
7
0
0
14
7
% D
% Glu:
40
0
0
7
0
0
20
0
7
0
14
14
34
0
0
% E
% Phe:
7
7
0
0
0
7
0
0
7
0
0
0
0
0
0
% F
% Gly:
7
0
0
0
0
0
7
0
0
14
0
0
0
14
7
% G
% His:
0
0
0
7
0
0
7
0
0
0
0
7
0
7
7
% H
% Ile:
7
0
0
7
14
7
7
0
0
0
0
0
14
0
0
% I
% Lys:
0
0
7
7
7
0
7
7
7
0
7
7
0
7
7
% K
% Leu:
7
40
7
7
7
47
0
0
14
0
7
7
0
0
0
% L
% Met:
0
0
14
0
0
0
0
0
7
0
0
0
0
0
0
% M
% Asn:
0
14
0
0
7
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
0
14
0
0
7
0
20
0
0
0
0
0
0
7
% P
% Gln:
0
0
7
7
7
7
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
7
34
0
0
0
14
0
7
0
0
14
40
0
% R
% Ser:
7
0
0
7
0
14
40
40
40
47
20
7
14
7
7
% S
% Thr:
0
7
20
7
7
0
0
0
0
7
7
40
0
7
0
% T
% Val:
7
7
7
7
27
7
7
7
0
7
14
7
0
0
0
% V
% Trp:
0
7
7
0
0
0
0
0
0
7
0
0
7
0
0
% W
% Tyr:
0
7
0
0
14
0
0
0
0
0
0
0
7
7
40
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _