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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ATG4D
All Species:
27.88
Human Site:
Y398
Identified Species:
43.81
UniProt:
Q86TL0
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86TL0
NP_116274.3
474
52922
Y398
P
S
C
T
V
G
F
Y
A
G
D
R
K
E
F
Chimpanzee
Pan troglodytes
XP_512373
411
46398
A336
S
C
T
V
G
F
Y
A
G
D
R
K
E
F
E
Rhesus Macaque
Macaca mulatta
XP_001101860
474
52893
Y398
P
S
C
T
V
G
F
Y
A
G
D
R
K
E
F
Dog
Lupus familis
XP_542069
473
52729
Y397
P
S
C
T
V
G
F
Y
A
G
D
Q
K
E
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8BGV9
474
52892
Y398
P
S
C
T
V
G
F
Y
A
G
N
R
K
E
F
Rat
Rattus norvegicus
NP_001094483
473
52805
Y397
P
S
C
T
V
G
F
Y
A
G
N
R
K
E
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514370
459
52127
R376
S
P
K
K
M
S
F
R
K
M
D
P
S
C
T
Chicken
Gallus gallus
Q6PZ02
393
44512
A318
A
E
L
D
P
S
I
A
V
G
F
F
C
H
T
Frog
Xenopus laevis
Q68FJ9
469
52793
I384
H
C
N
S
P
R
K
I
S
I
T
R
M
D
P
Zebra Danio
Brachydanio rerio
Q6DG88
394
44435
I319
I
C
E
L
D
P
S
I
A
A
G
F
F
C
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650452
668
74736
Y552
P
S
C
C
I
G
F
Y
C
A
T
K
S
D
F
Honey Bee
Apis mellifera
XP_393739
477
54008
Y400
P
S
C
C
V
G
F
Y
F
H
N
K
M
Q
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786847
723
81931
Y642
P
S
C
T
I
G
F
Y
I
R
T
E
E
Q
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8S929
467
51510
F361
G
V
Q
E
D
K
G
F
Y
L
D
P
H
E
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7S3X7
506
55337
Q431
C
H
T
R
R
L
R
Q
L
H
I
G
D
M
D
Conservation
Percent
Protein Identity:
100
84.8
98.5
94.3
N.A.
86.2
86.7
N.A.
44
26.5
53.3
27
N.A.
30.3
35
N.A.
30.8
Protein Similarity:
100
85.6
98.9
96.1
N.A.
90.9
91.1
N.A.
59.4
39.6
68.9
41.9
N.A.
44.4
49.2
N.A.
41.9
P-Site Identity:
100
0
100
93.3
N.A.
93.3
93.3
N.A.
13.3
6.6
6.6
6.6
N.A.
46.6
53.3
N.A.
53.3
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
20
6.6
26.6
6.6
N.A.
66.6
73.3
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.4
N.A.
22.1
Protein Similarity:
N.A.
N.A.
N.A.
42.4
N.A.
36.3
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
0
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
14
40
14
0
0
0
0
0
% A
% Cys:
7
20
54
14
0
0
0
0
7
0
0
0
7
14
0
% C
% Asp:
0
0
0
7
14
0
0
0
0
7
34
0
7
14
7
% D
% Glu:
0
7
7
7
0
0
0
0
0
0
0
7
14
40
7
% E
% Phe:
0
0
0
0
0
7
60
7
7
0
7
14
7
7
54
% F
% Gly:
7
0
0
0
7
54
7
0
7
40
7
7
0
0
0
% G
% His:
7
7
0
0
0
0
0
0
0
14
0
0
7
7
0
% H
% Ile:
7
0
0
0
14
0
7
14
7
7
7
0
0
0
0
% I
% Lys:
0
0
7
7
0
7
7
0
7
0
0
20
34
0
0
% K
% Leu:
0
0
7
7
0
7
0
0
7
7
0
0
0
0
0
% L
% Met:
0
0
0
0
7
0
0
0
0
7
0
0
14
7
0
% M
% Asn:
0
0
7
0
0
0
0
0
0
0
20
0
0
0
0
% N
% Pro:
54
7
0
0
14
7
0
0
0
0
0
14
0
0
7
% P
% Gln:
0
0
7
0
0
0
0
7
0
0
0
7
0
14
7
% Q
% Arg:
0
0
0
7
7
7
7
7
0
7
7
34
0
0
0
% R
% Ser:
14
54
0
7
0
14
7
0
7
0
0
0
14
0
0
% S
% Thr:
0
0
14
40
0
0
0
0
0
0
20
0
0
0
14
% T
% Val:
0
7
0
7
40
0
0
0
7
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
54
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _