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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DDX53 All Species: 10
Human Site: T246 Identified Species: 24.44
UniProt: Q86TM3 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86TM3 NP_874358.2 631 71154 T246 R V G I V K P T P I Q S Q A W
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001087519 592 67036 L222 I I L Q G I D L I E V A Q T G
Dog Lupus familis XP_853740 646 73189 T264 R A G F Q K P T P I Q S Q A W
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus XP_001060057 620 69575 T240 R A G F Q K P T P I Q S Q A W
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_426195 445 49951 K81 E E V E L W R K E N N N I I C
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P19109 719 78529 T305 R Q G Y K A P T A I Q A Q G W
Honey Bee Apis mellifera XP_394925 593 68127 G223 L S G R D L I G I A Q T G T G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8W4R3 591 64603 K215 I A E T G S G K T L A Y L L P
Baker's Yeast Sacchar. cerevisiae P24783 546 60981 A182 I N A Q P L L A P G D G P I V
Red Bread Mold Neurospora crassa Q7SBC6 562 60181 P198 I V H I N A Q P L L A P G D G
Conservation
Percent
Protein Identity: 100 N.A. 84.4 65.3 N.A. N.A. 60.2 N.A. N.A. 46.9 N.A. N.A. N.A. 26.5 40.8 N.A. N.A.
Protein Similarity: 100 N.A. 88.2 78.7 N.A. N.A. 75.5 N.A. N.A. 57.6 N.A. N.A. N.A. 45.9 59.1 N.A. N.A.
P-Site Identity: 100 N.A. 6.6 80 N.A. N.A. 80 N.A. N.A. 0 N.A. N.A. N.A. 53.3 13.3 N.A. N.A.
P-Site Similarity: 100 N.A. 20 80 N.A. N.A. 80 N.A. N.A. 13.3 N.A. N.A. N.A. 60 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 35.6 35.3 33.1
Protein Similarity: N.A. N.A. N.A. 53.8 54.2 51.5
P-Site Identity: N.A. N.A. N.A. 0 6.6 13.3
P-Site Similarity: N.A. N.A. N.A. 6.6 6.6 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 30 10 0 0 20 0 10 10 10 20 20 0 30 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 0 0 0 0 10 0 10 0 0 0 10 0 0 10 0 % D
% Glu: 10 10 10 10 0 0 0 0 10 10 0 0 0 0 0 % E
% Phe: 0 0 0 20 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 50 0 20 0 10 10 0 10 0 10 20 10 30 % G
% His: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 40 10 0 20 0 10 10 0 20 40 0 0 10 20 0 % I
% Lys: 0 0 0 0 10 30 0 20 0 0 0 0 0 0 0 % K
% Leu: 10 0 10 0 10 20 10 10 10 20 0 0 10 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 0 10 0 0 0 0 10 10 10 0 0 0 % N
% Pro: 0 0 0 0 10 0 40 10 40 0 0 10 10 0 10 % P
% Gln: 0 10 0 20 20 0 10 0 0 0 50 0 50 0 0 % Q
% Arg: 40 0 0 10 0 0 10 0 0 0 0 0 0 0 0 % R
% Ser: 0 10 0 0 0 10 0 0 0 0 0 30 0 0 0 % S
% Thr: 0 0 0 10 0 0 0 40 10 0 0 10 0 20 0 % T
% Val: 0 20 10 0 10 0 0 0 0 0 10 0 0 0 10 % V
% Trp: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 40 % W
% Tyr: 0 0 0 10 0 0 0 0 0 0 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _