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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISCA2
All Species:
35.76
Human Site:
S145
Identified Species:
60.51
UniProt:
Q86U28
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86U28
NP_919255.2
154
16476
S145
P
Q
A
Q
Q
G
C
S
C
G
S
S
F
S
I
Chimpanzee
Pan troglodytes
XP_001143075
195
21038
S186
P
Q
A
Q
Q
G
C
S
C
G
S
S
F
S
I
Rhesus Macaque
Macaca mulatta
XP_001094302
154
16440
S145
P
Q
A
Q
Q
G
C
S
C
G
S
S
F
S
I
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9DCB8
154
16699
S145
P
Q
A
Q
Q
G
C
S
C
G
S
S
F
S
V
Rat
Rattus norvegicus
NP_001102748
154
16661
S145
P
Q
A
Q
Q
G
C
S
C
G
S
S
F
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_421267
187
20319
F161
G
S
L
Q
R
V
L
F
D
L
S
P
A
E
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001922511
155
16837
S146
P
Q
A
E
H
G
C
S
C
G
S
S
F
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651267
139
15228
C131
L
A
E
Q
G
C
S
C
G
S
S
F
S
I
K
Honey Bee
Apis mellifera
XP_001120329
157
17588
S148
P
L
A
E
Q
G
C
S
C
G
A
S
F
S
I
Nematode Worm
Caenorhab. elegans
NP_496981
134
14840
G126
A
E
K
G
C
S
C
G
S
S
F
A
P
K
M
Sea Urchin
Strong. purpuratus
XP_783841
135
14758
C127
G
A
E
M
G
C
S
C
G
A
S
F
S
F
K
Poplar Tree
Populus trichocarpa
XP_002308154
153
16947
S144
P
S
A
V
G
G
C
S
C
K
S
S
F
M
V
Maize
Zea mays
NP_001151226
158
17226
S150
P
S
A
V
G
G
C
S
C
K
S
S
F
M
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8LCY2
158
17395
S149
P
S
A
V
G
G
C
S
C
K
S
S
F
M
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.4
97.4
N.A.
N.A.
83.7
83.7
N.A.
N.A.
53.4
N.A.
52.2
N.A.
46.7
47.1
43.5
47.4
Protein Similarity:
100
78.4
97.4
N.A.
N.A.
86.3
86.3
N.A.
N.A.
62.5
N.A.
66.4
N.A.
62.3
64.9
64.2
68.1
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
100
N.A.
N.A.
13.3
N.A.
80
N.A.
13.3
80
6.6
6.6
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
N.A.
20
N.A.
93.3
N.A.
13.3
93.3
26.6
6.6
Percent
Protein Identity:
50
44.9
N.A.
41.7
N.A.
N.A.
Protein Similarity:
62.3
58.8
N.A.
60.1
N.A.
N.A.
P-Site Identity:
60
60
N.A.
60
N.A.
N.A.
P-Site Similarity:
66.6
66.6
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
15
72
0
0
0
0
0
0
8
8
8
8
0
0
% A
% Cys:
0
0
0
0
8
15
79
15
72
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
8
15
15
0
0
0
0
0
0
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
8
15
72
8
0
% F
% Gly:
15
0
0
8
36
72
0
8
15
50
0
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
36
% I
% Lys:
0
0
8
0
0
0
0
0
0
22
0
0
0
8
15
% K
% Leu:
8
8
8
0
0
0
8
0
0
8
0
0
0
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
22
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
72
0
0
0
0
0
0
0
0
0
0
8
8
0
8
% P
% Gln:
0
43
0
50
43
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
29
0
0
0
8
15
72
8
15
86
72
15
50
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
22
0
8
0
0
0
0
0
0
0
0
36
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _