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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL3
All Species:
38.79
Human Site:
S266
Identified Species:
71.11
UniProt:
Q86U44
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86U44
NP_062826.2
580
64474
S266
S
I
V
E
K
F
R
S
R
G
R
A
Q
V
Q
Chimpanzee
Pan troglodytes
XP_001154543
592
65806
S266
S
I
V
E
K
F
R
S
R
G
R
A
Q
V
Q
Rhesus Macaque
Macaca mulatta
XP_001097947
580
64400
S266
S
I
V
E
K
F
R
S
R
G
R
A
Q
V
Q
Dog
Lupus familis
XP_532627
580
64523
S266
S
I
V
E
K
F
R
S
R
G
R
A
Q
V
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8C3P7
580
64598
S266
S
I
V
E
K
F
R
S
R
G
R
A
Q
V
Q
Rat
Rattus norvegicus
NP_001019965
580
64667
S266
S
I
V
E
K
F
R
S
R
G
R
A
Q
V
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084701
573
63870
S259
S
I
V
E
K
F
R
S
R
G
R
A
Q
V
Q
Zebra Danio
Brachydanio rerio
NP_997945
584
64592
S271
S
I
V
E
K
F
R
S
R
G
R
A
Q
V
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCE6
608
68082
A281
K
V
P
K
T
E
S
A
A
E
D
G
E
I
I
Honey Bee
Apis mellifera
XP_624299
556
62595
E254
N
G
G
P
G
F
A
E
K
C
K
K
L
H
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002299435
754
83906
T386
A
V
A
A
K
F
K
T
K
G
G
S
Q
L
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O82486
685
76626
S361
A
T
A
A
K
F
K
S
K
G
G
S
Q
V
K
Baker's Yeast
Sacchar. cerevisiae
P41833
600
69377
Q325
I
K
K
A
L
P
A
Q
W
I
R
C
D
V
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
99.6
98.4
N.A.
96.9
96.7
N.A.
N.A.
N.A.
76.9
70.2
N.A.
45
51.2
N.A.
N.A.
Protein Similarity:
100
97.9
99.8
98.7
N.A.
97.7
97.5
N.A.
N.A.
N.A.
85.5
80.4
N.A.
59.8
68
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
100
N.A.
0
6.6
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
100
N.A.
33.3
26.6
N.A.
N.A.
Percent
Protein Identity:
36.2
N.A.
N.A.
39.4
33
N.A.
Protein Similarity:
50.2
N.A.
N.A.
54.1
50.8
N.A.
P-Site Identity:
26.6
N.A.
N.A.
40
13.3
N.A.
P-Site Similarity:
80
N.A.
N.A.
73.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
16
24
0
0
16
8
8
0
0
62
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% D
% Glu:
0
0
0
62
0
8
0
8
0
8
0
0
8
0
0
% E
% Phe:
0
0
0
0
0
85
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
8
8
0
8
0
0
0
0
77
16
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
8
62
0
0
0
0
0
0
0
8
0
0
0
8
8
% I
% Lys:
8
8
8
8
77
0
16
0
24
0
8
8
0
0
16
% K
% Leu:
0
0
0
0
8
0
0
0
0
0
0
0
8
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
8
0
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
8
0
0
0
0
77
0
62
% Q
% Arg:
0
0
0
0
0
0
62
0
62
0
70
0
0
0
8
% R
% Ser:
62
0
0
0
0
0
8
70
0
0
0
16
0
0
0
% S
% Thr:
0
8
0
0
8
0
0
8
0
0
0
0
0
0
0
% T
% Val:
0
16
62
0
0
0
0
0
0
0
0
0
0
77
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _