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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL3
All Species:
24.24
Human Site:
S339
Identified Species:
44.44
UniProt:
Q86U44
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86U44
NP_062826.2
580
64474
S339
E
I
D
A
C
M
D
S
E
A
P
G
S
K
D
Chimpanzee
Pan troglodytes
XP_001154543
592
65806
S339
E
I
D
A
C
M
D
S
E
A
P
G
S
K
D
Rhesus Macaque
Macaca mulatta
XP_001097947
580
64400
S339
E
I
D
A
C
M
D
S
E
A
P
G
S
K
D
Dog
Lupus familis
XP_532627
580
64523
S339
E
I
D
A
C
M
D
S
E
A
P
G
S
K
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8C3P7
580
64598
S339
E
I
D
A
C
V
D
S
E
S
P
G
S
K
E
Rat
Rattus norvegicus
NP_001019965
580
64667
S339
E
I
D
A
C
V
D
S
E
S
P
G
S
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084701
573
63870
P332
E
I
D
A
W
V
E
P
G
G
T
A
M
G
T
Zebra Danio
Brachydanio rerio
NP_997945
584
64592
A344
E
I
D
S
P
P
E
A
E
G
D
A
L
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCE6
608
68082
I362
E
V
D
T
L
P
H
I
N
T
N
K
P
T
D
Honey Bee
Apis mellifera
XP_624299
556
62595
S324
N
K
G
L
T
I
D
S
K
N
G
N
N
T
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002299435
754
83906
V459
E
L
D
P
T
P
D
V
S
P
M
A
M
G
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O82486
685
76626
M434
E
L
D
M
A
D
A
M
M
A
G
P
D
K
A
Baker's Yeast
Sacchar. cerevisiae
P41833
600
69377
K394
G
R
A
I
E
L
G
K
E
S
L
N
N
W
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
99.6
98.4
N.A.
96.9
96.7
N.A.
N.A.
N.A.
76.9
70.2
N.A.
45
51.2
N.A.
N.A.
Protein Similarity:
100
97.9
99.8
98.7
N.A.
97.7
97.5
N.A.
N.A.
N.A.
85.5
80.4
N.A.
59.8
68
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
80
80
N.A.
N.A.
N.A.
26.6
26.6
N.A.
20
13.3
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
N.A.
40
46.6
N.A.
26.6
33.3
N.A.
N.A.
Percent
Protein Identity:
36.2
N.A.
N.A.
39.4
33
N.A.
Protein Similarity:
50.2
N.A.
N.A.
54.1
50.8
N.A.
P-Site Identity:
20
N.A.
N.A.
26.6
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
33.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
54
8
0
8
8
0
39
0
24
0
0
16
% A
% Cys:
0
0
0
0
47
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
85
0
0
8
62
0
0
0
8
0
8
0
39
% D
% Glu:
85
0
0
0
8
0
16
0
62
0
0
0
0
0
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
8
0
0
0
8
0
8
16
16
47
0
24
8
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
62
0
8
0
8
0
8
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
0
8
8
0
0
8
0
54
0
% K
% Leu:
0
16
0
8
8
8
0
0
0
0
8
0
8
0
0
% L
% Met:
0
0
0
8
0
31
0
8
8
0
8
0
16
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
8
8
8
16
16
0
0
% N
% Pro:
0
0
0
8
8
24
0
8
0
8
47
8
8
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
8
0
0
0
54
8
24
0
0
47
0
8
% S
% Thr:
0
0
0
8
16
0
0
0
0
8
8
0
0
16
8
% T
% Val:
0
8
0
0
0
24
0
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _