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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL3
All Species:
22.73
Human Site:
T112
Identified Species:
41.67
UniProt:
Q86U44
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86U44
NP_062826.2
580
64474
T112
S
T
P
D
A
P
A
T
Q
D
G
V
E
S
L
Chimpanzee
Pan troglodytes
XP_001154543
592
65806
T112
S
T
P
D
A
P
A
T
Q
D
G
V
E
S
L
Rhesus Macaque
Macaca mulatta
XP_001097947
580
64400
T112
S
T
P
D
A
P
A
T
Q
D
G
V
E
S
L
Dog
Lupus familis
XP_532627
580
64523
T112
S
T
P
D
A
P
A
T
Q
D
G
V
E
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8C3P7
580
64598
T112
S
T
P
D
A
P
A
T
Q
D
G
V
E
S
L
Rat
Rattus norvegicus
NP_001019965
580
64667
T112
S
T
P
D
A
P
A
T
Q
D
G
V
E
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084701
573
63870
R112
T
P
D
F
P
V
T
R
Q
G
V
E
S
L
L
Zebra Danio
Brachydanio rerio
NP_997945
584
64592
L112
S
C
I
Q
S
L
L
L
K
F
S
A
Q
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCE6
608
68082
G112
V
T
I
G
T
E
A
G
C
E
I
I
S
V
Q
Honey Bee
Apis mellifera
XP_624299
556
62595
K112
D
I
H
K
I
L
E
K
F
A
A
Q
D
I
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002299435
754
83906
P150
E
C
L
L
Q
R
V
P
F
N
P
I
D
S
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O82486
685
76626
D112
N
Q
R
D
A
E
A
D
G
S
S
G
S
P
M
Baker's Yeast
Sacchar. cerevisiae
P41833
600
69377
R170
N
R
L
Q
N
L
L
R
E
K
P
S
S
F
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
99.6
98.4
N.A.
96.9
96.7
N.A.
N.A.
N.A.
76.9
70.2
N.A.
45
51.2
N.A.
N.A.
Protein Similarity:
100
97.9
99.8
98.7
N.A.
97.7
97.5
N.A.
N.A.
N.A.
85.5
80.4
N.A.
59.8
68
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
N.A.
13.3
13.3
N.A.
13.3
0
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
N.A.
20
33.3
N.A.
26.6
13.3
N.A.
N.A.
Percent
Protein Identity:
36.2
N.A.
N.A.
39.4
33
N.A.
Protein Similarity:
50.2
N.A.
N.A.
54.1
50.8
N.A.
P-Site Identity:
6.6
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
33.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
54
0
62
0
0
8
8
8
0
0
0
% A
% Cys:
0
16
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
8
0
8
54
0
0
0
8
0
47
0
0
16
0
0
% D
% Glu:
8
0
0
0
0
16
8
0
8
8
0
8
47
8
0
% E
% Phe:
0
0
0
8
0
0
0
0
16
8
0
0
0
8
0
% F
% Gly:
0
0
0
8
0
0
0
8
8
8
47
8
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
16
0
8
0
0
0
0
0
8
16
0
8
0
% I
% Lys:
0
0
0
8
0
0
0
8
8
8
0
0
0
0
0
% K
% Leu:
0
0
16
8
0
24
16
8
0
0
0
0
0
8
62
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
16
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
8
47
0
8
47
0
8
0
0
16
0
0
8
0
% P
% Gln:
0
8
0
16
8
0
0
0
54
0
0
8
8
0
16
% Q
% Arg:
0
8
8
0
0
8
0
16
0
0
0
0
0
0
0
% R
% Ser:
54
0
0
0
8
0
0
0
0
8
16
8
31
54
8
% S
% Thr:
8
54
0
0
8
0
8
47
0
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
8
8
0
0
0
8
47
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _