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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL3
All Species:
30.61
Human Site:
Y278
Identified Species:
56.11
UniProt:
Q86U44
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86U44
NP_062826.2
580
64474
Y278
Q
V
Q
E
F
C
D
Y
G
T
K
E
E
C
M
Chimpanzee
Pan troglodytes
XP_001154543
592
65806
Y278
Q
V
Q
E
F
C
D
Y
G
T
K
E
E
C
M
Rhesus Macaque
Macaca mulatta
XP_001097947
580
64400
Y278
Q
V
Q
E
F
C
D
Y
G
T
K
E
E
C
M
Dog
Lupus familis
XP_532627
580
64523
Y278
Q
V
Q
E
F
C
D
Y
G
T
K
E
E
C
M
Cat
Felis silvestris
Mouse
Mus musculus
Q8C3P7
580
64598
Y278
Q
V
Q
E
F
C
D
Y
G
T
K
E
E
C
M
Rat
Rattus norvegicus
NP_001019965
580
64667
Y278
Q
V
Q
E
F
C
D
Y
G
T
K
E
E
C
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084701
573
63870
F271
Q
V
Q
E
F
C
D
F
G
T
K
E
E
C
M
Zebra Danio
Brachydanio rerio
NP_997945
584
64592
Y283
Q
V
Q
E
F
C
D
Y
G
T
K
E
E
C
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCE6
608
68082
N293
E
I
I
A
E
V
I
N
N
C
E
A
E
S
Q
Honey Bee
Apis mellifera
XP_624299
556
62595
Q266
L
H
F
K
K
I
I
Q
S
H
T
D
E
S
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002299435
754
83906
A398
Q
L
K
E
Y
C
S
A
L
T
K
E
D
C
R
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O82486
685
76626
Y373
Q
V
K
Y
Y
C
R
Y
L
T
K
E
D
C
R
Baker's Yeast
Sacchar. cerevisiae
P41833
600
69377
R337
D
V
R
K
F
D
F
R
V
L
G
K
F
S
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
99.6
98.4
N.A.
96.9
96.7
N.A.
N.A.
N.A.
76.9
70.2
N.A.
45
51.2
N.A.
N.A.
Protein Similarity:
100
97.9
99.8
98.7
N.A.
97.7
97.5
N.A.
N.A.
N.A.
85.5
80.4
N.A.
59.8
68
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
93.3
N.A.
6.6
6.6
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
N.A.
100
100
N.A.
26.6
26.6
N.A.
N.A.
Percent
Protein Identity:
36.2
N.A.
N.A.
39.4
33
N.A.
Protein Similarity:
50.2
N.A.
N.A.
54.1
50.8
N.A.
P-Site Identity:
46.6
N.A.
N.A.
53.3
13.3
N.A.
P-Site Similarity:
73.3
N.A.
N.A.
73.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
8
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
77
0
0
0
8
0
0
0
77
0
% C
% Asp:
8
0
0
0
0
8
62
0
0
0
0
8
16
0
0
% D
% Glu:
8
0
0
70
8
0
0
0
0
0
8
77
77
0
0
% E
% Phe:
0
0
8
0
70
0
8
8
0
0
0
0
8
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
62
0
8
0
0
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
8
16
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
16
16
8
0
0
0
0
0
77
8
0
0
0
% K
% Leu:
8
8
0
0
0
0
0
0
16
8
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% M
% Asn:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
77
0
62
0
0
0
0
8
0
0
0
0
0
0
8
% Q
% Arg:
0
0
8
0
0
0
8
8
0
0
0
0
0
0
16
% R
% Ser:
0
0
0
0
0
0
8
0
8
0
0
0
0
24
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
77
8
0
0
0
0
% T
% Val:
0
77
0
0
0
8
0
0
8
0
0
0
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
16
0
0
62
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _