KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL3
All Species:
42.12
Human Site:
Y569
Identified Species:
77.22
UniProt:
Q86U44
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86U44
NP_062826.2
580
64474
Y569
V
A
R
F
K
Q
R
Y
P
D
G
I
I
S
K
Chimpanzee
Pan troglodytes
XP_001154543
592
65806
Y581
V
A
R
F
K
Q
R
Y
P
D
G
I
I
S
K
Rhesus Macaque
Macaca mulatta
XP_001097947
580
64400
Y569
V
A
R
F
K
Q
R
Y
P
D
G
I
I
S
K
Dog
Lupus familis
XP_532627
580
64523
Y569
V
A
R
F
K
Q
R
Y
P
D
G
I
I
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8C3P7
580
64598
Y569
V
A
R
F
K
Q
R
Y
P
D
G
I
I
S
K
Rat
Rattus norvegicus
NP_001019965
580
64667
Y569
V
A
R
F
K
H
R
Y
P
D
G
V
I
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084701
573
63870
Y562
V
A
Q
F
K
Q
K
Y
P
D
G
V
I
G
M
Zebra Danio
Brachydanio rerio
NP_997945
584
64592
Y573
V
A
R
F
K
K
R
Y
P
D
G
V
I
S
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCE6
608
68082
Y587
I
T
Q
F
Q
K
R
Y
P
D
G
N
C
M
S
Honey Bee
Apis mellifera
XP_624299
556
62595
Y545
I
K
A
F
K
K
R
Y
P
D
G
N
S
M
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002299435
754
83906
Y688
R
A
R
F
K
A
A
Y
P
D
V
V
V
Q
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O82486
685
76626
Y655
R
A
R
F
K
A
S
Y
P
E
I
D
V
Q
P
Baker's Yeast
Sacchar. cerevisiae
P41833
600
69377
Q588
E
S
K
Q
Q
Q
K
Q
Q
F
Q
T
L
N
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
99.6
98.4
N.A.
96.9
96.7
N.A.
N.A.
N.A.
76.9
70.2
N.A.
45
51.2
N.A.
N.A.
Protein Similarity:
100
97.9
99.8
98.7
N.A.
97.7
97.5
N.A.
N.A.
N.A.
85.5
80.4
N.A.
59.8
68
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
86.6
N.A.
N.A.
N.A.
66.6
86.6
N.A.
40
53.3
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
N.A.
86.6
100
N.A.
66.6
66.6
N.A.
N.A.
Percent
Protein Identity:
36.2
N.A.
N.A.
39.4
33
N.A.
Protein Similarity:
50.2
N.A.
N.A.
54.1
50.8
N.A.
P-Site Identity:
46.6
N.A.
N.A.
40
6.6
N.A.
P-Site Similarity:
60
N.A.
N.A.
53.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
77
8
0
0
16
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
85
0
8
0
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
93
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
77
0
0
8
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
16
0
0
0
0
0
0
0
0
0
8
39
62
0
0
% I
% Lys:
0
8
8
0
85
24
16
0
0
0
0
0
0
0
62
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
16
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
16
0
8
8
% N
% Pro:
0
0
0
0
0
0
0
0
93
0
0
0
0
0
16
% P
% Gln:
0
0
16
8
16
54
0
8
8
0
8
0
0
16
0
% Q
% Arg:
16
0
70
0
0
0
70
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
8
0
0
0
0
0
8
54
8
% S
% Thr:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% T
% Val:
62
0
0
0
0
0
0
0
0
0
8
31
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
93
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _