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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: YRDC All Species: 5.45
Human Site: S37 Identified Species: 9.23
UniProt: Q86U90 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86U90 NP_078916.3 279 29328 S37 G R L F R P P S P A P A A P G
Chimpanzee Pan troglodytes XP_513328 279 29381 S37 G R L F R P P S P A P A A P G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_539586 274 28633 P37 R G R L M R E P S R L L R L P
Cat Felis silvestris
Mouse Mus musculus Q3U5F4 280 29435 P37 G C R L L R P P E P A P A L P
Rat Rattus norvegicus Q499R4 280 29212 P37 G C R L L R P P A P A P A L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511974 148 15850
Chicken Gallus gallus XP_417757 255 26969 A37 L L P L P G S A A R P E P R G
Frog Xenopus laevis NP_001082498 236 25547 S18 G E N G R C T S R P T R D M K
Zebra Danio Brachydanio rerio NP_001077336 235 25902 D18 R I S S N F S D D L T L H Q P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001027444 248 27575 P31 Q A S E L R T P V C A V G D E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793502 222 24027
Poplar Tree Populus trichocarpa XP_002313460 232 24943 N14 N C H V D V Q N K L E V V R P
Maize Zea mays NP_001148954 275 29299 Q37 K V R R L P S Q H E T K S Q V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_974970 288 31285 W44 N Q S R R L R W G L Q K K M V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 84.2 N.A. 85.3 86 N.A. 39.4 61.6 53 50.1 N.A. 39.4 N.A. N.A. 41.2
Protein Similarity: 100 99.6 N.A. 89.2 N.A. 89.2 90.3 N.A. 44.7 73.4 66.3 64.1 N.A. 58.4 N.A. N.A. 55.2
P-Site Identity: 100 100 N.A. 0 N.A. 20 20 N.A. 0 13.3 20 0 N.A. 0 N.A. N.A. 0
P-Site Similarity: 100 100 N.A. 0 N.A. 20 20 N.A. 0 20 20 0 N.A. 0 N.A. N.A. 0
Percent
Protein Identity: 38.3 36.9 N.A. 37.8 N.A. N.A.
Protein Similarity: 55.2 55.5 N.A. 54.1 N.A. N.A.
P-Site Identity: 0 6.6 N.A. 6.6 N.A. N.A.
P-Site Similarity: 6.6 13.3 N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 0 8 15 15 22 15 29 0 0 % A
% Cys: 0 22 0 0 0 8 0 0 0 8 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 0 8 8 0 0 0 8 8 0 % D
% Glu: 0 8 0 8 0 0 8 0 8 8 8 8 0 0 8 % E
% Phe: 0 0 0 15 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 36 8 0 8 0 8 0 0 8 0 0 0 8 0 22 % G
% His: 0 0 8 0 0 0 0 0 8 0 0 0 8 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 0 0 0 0 0 0 0 8 0 0 15 8 0 8 % K
% Leu: 8 8 15 29 29 8 0 0 0 22 8 15 0 22 0 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 0 15 0 % M
% Asn: 15 0 8 0 8 0 0 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 8 0 8 22 29 29 15 22 22 15 8 15 36 % P
% Gln: 8 8 0 0 0 0 8 8 0 0 8 0 0 15 0 % Q
% Arg: 15 15 29 15 29 29 8 0 8 15 0 8 8 15 0 % R
% Ser: 0 0 22 8 0 0 22 22 8 0 0 0 8 0 0 % S
% Thr: 0 0 0 0 0 0 15 0 0 0 22 0 0 0 0 % T
% Val: 0 8 0 8 0 8 0 0 8 0 0 15 8 0 15 % V
% Trp: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _