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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: YRDC All Species: 25.15
Human Site: T239 Identified Species: 42.56
UniProt: Q86U90 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86U90 NP_078916.3 279 29328 T239 P E C R L G S T V V D L S V P
Chimpanzee Pan troglodytes XP_513328 279 29381 T239 P E C R L G S T V V D L S V P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_539586 274 28633 T232 P E Y R L G S T V V D L S V P
Cat Felis silvestris
Mouse Mus musculus Q3U5F4 280 29435 T240 P E C R L G S T V V D L S V P
Rat Rattus norvegicus Q499R4 280 29212 T240 P E C R L G S T V V D L S V P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511974 148 15850 V110 C R L G S T V V D L S V P G K
Chicken Gallus gallus XP_417757 255 26969 S217 S P E C R L G S T V V D L S V
Frog Xenopus laevis NP_001082498 236 25547 L197 H S S P E C R L G S T V V D L
Zebra Danio Brachydanio rerio NP_001077336 235 25902 V197 K S R L G S T V V D L S V C G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001027444 248 27575 S210 T E E R R L A S T V I D L A T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793502 222 24027 S184 S E E S R Q G S T V V D L S V
Poplar Tree Populus trichocarpa XP_002313460 232 24943 T194 P S N R A G S T I V D L T R P
Maize Zea mays NP_001148954 275 29299 L232 Y V F D G G V L P S G R A G S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_974970 288 31285 T248 G S T I V D L T K V G K Y K I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 84.2 N.A. 85.3 86 N.A. 39.4 61.6 53 50.1 N.A. 39.4 N.A. N.A. 41.2
Protein Similarity: 100 99.6 N.A. 89.2 N.A. 89.2 90.3 N.A. 44.7 73.4 66.3 64.1 N.A. 58.4 N.A. N.A. 55.2
P-Site Identity: 100 100 N.A. 93.3 N.A. 100 100 N.A. 0 6.6 0 6.6 N.A. 20 N.A. N.A. 13.3
P-Site Similarity: 100 100 N.A. 93.3 N.A. 100 100 N.A. 13.3 13.3 6.6 13.3 N.A. 33.3 N.A. N.A. 20
Percent
Protein Identity: 38.3 36.9 N.A. 37.8 N.A. N.A.
Protein Similarity: 55.2 55.5 N.A. 54.1 N.A. N.A.
P-Site Identity: 60 6.6 N.A. 13.3 N.A. N.A.
P-Site Similarity: 73.3 13.3 N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 8 0 0 0 0 0 8 8 0 % A
% Cys: 8 0 29 8 0 8 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 8 0 8 0 0 8 8 43 22 0 8 0 % D
% Glu: 0 50 22 0 8 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 8 15 50 15 0 8 0 15 0 0 15 8 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 8 0 8 0 0 0 8 % I
% Lys: 8 0 0 0 0 0 0 0 8 0 0 8 0 8 8 % K
% Leu: 0 0 8 8 36 15 8 15 0 8 8 43 22 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 43 8 0 8 0 0 0 0 8 0 0 0 8 0 43 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 8 8 50 22 0 8 0 0 0 0 8 0 8 0 % R
% Ser: 15 29 8 8 8 8 43 22 0 15 8 8 36 15 8 % S
% Thr: 8 0 8 0 0 8 8 50 22 0 8 0 8 0 8 % T
% Val: 0 8 0 0 8 0 15 15 43 72 15 15 15 36 15 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 8 0 0 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _