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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: YRDC All Species: 20.61
Human Site: Y269 Identified Species: 34.87
UniProt: Q86U90 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86U90 NP_078916.3 279 29328 Y269 T A I L Q Q K Y G L L P S H A
Chimpanzee Pan troglodytes XP_513328 279 29381 Y269 T A I L Q Q K Y G L L P S H A
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_539586 274 28633 Y262 T A I L R Q K Y G L L P S H G
Cat Felis silvestris
Mouse Mus musculus Q3U5F4 280 29435 Y270 T S I L Q Q K Y G L L P S Q G
Rat Rattus norvegicus Q499R4 280 29212 Y270 T A I L Q G K Y G L L P S Q G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511974 148 15850 G139 D I L Q R K Y G L Q P S E D S
Chicken Gallus gallus XP_417757 255 26969 Q246 S T V E I L R Q K Y G L V P E
Frog Xenopus laevis NP_001082498 236 25547 S227 T H T V D I L S N S Y G L L P
Zebra Danio Brachydanio rerio NP_001077336 235 25902 Y226 V Q I L E G R Y G L L E D P D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001027444 248 27575 E239 P T L S L M E E F G I R E L K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793502 222 24027 G213 K T V K I L N G K Y H L K E K
Poplar Tree Populus trichocarpa XP_002313460 232 24943 H223 T L A I L E K H S L V E E A P
Maize Zea mays NP_001148954 275 29299 T262 D G S S R K E T A A V L G K F
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_974970 288 31285 E279 Y L L E E E E E E D H K E K R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 84.2 N.A. 85.3 86 N.A. 39.4 61.6 53 50.1 N.A. 39.4 N.A. N.A. 41.2
Protein Similarity: 100 99.6 N.A. 89.2 N.A. 89.2 90.3 N.A. 44.7 73.4 66.3 64.1 N.A. 58.4 N.A. N.A. 55.2
P-Site Identity: 100 100 N.A. 86.6 N.A. 80 80 N.A. 0 0 6.6 40 N.A. 0 N.A. N.A. 0
P-Site Similarity: 100 100 N.A. 93.3 N.A. 86.6 80 N.A. 26.6 20 13.3 53.3 N.A. 20 N.A. N.A. 6.6
Percent
Protein Identity: 38.3 36.9 N.A. 37.8 N.A. N.A.
Protein Similarity: 55.2 55.5 N.A. 54.1 N.A. N.A.
P-Site Identity: 20 0 N.A. 0 N.A. N.A.
P-Site Similarity: 46.6 26.6 N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 29 8 0 0 0 0 0 8 8 0 0 0 8 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 15 0 0 0 8 0 0 0 0 8 0 0 8 8 8 % D
% Glu: 0 0 0 15 15 15 22 15 8 0 0 15 29 8 8 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 8 % F
% Gly: 0 8 0 0 0 15 0 15 43 8 8 8 8 0 22 % G
% His: 0 8 0 0 0 0 0 8 0 0 15 0 0 22 0 % H
% Ile: 0 8 43 8 15 8 0 0 0 0 8 0 0 0 0 % I
% Lys: 8 0 0 8 0 15 43 0 15 0 0 8 8 15 15 % K
% Leu: 0 15 22 43 15 15 8 0 8 50 43 22 8 15 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % N
% Pro: 8 0 0 0 0 0 0 0 0 0 8 36 0 15 15 % P
% Gln: 0 8 0 8 29 29 0 8 0 8 0 0 0 15 0 % Q
% Arg: 0 0 0 0 22 0 15 0 0 0 0 8 0 0 8 % R
% Ser: 8 8 8 15 0 0 0 8 8 8 0 8 36 0 8 % S
% Thr: 50 22 8 0 0 0 0 8 0 0 0 0 0 0 0 % T
% Val: 8 0 15 8 0 0 0 0 0 0 15 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 8 43 0 15 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _