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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM135
All Species:
30
Human Site:
S196
Identified Species:
55
UniProt:
Q86UB9
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86UB9
NP_075069.2
458
52291
S196
K
E
E
I
P
T
H
S
F
S
P
E
A
A
Y
Chimpanzee
Pan troglodytes
XP_001175336
458
52311
S196
K
E
E
I
P
T
H
S
F
S
P
E
A
A
Y
Rhesus Macaque
Macaca mulatta
XP_001104105
458
52398
S196
K
E
E
I
P
T
H
S
F
S
P
E
A
A
Y
Dog
Lupus familis
XP_848695
458
52312
S196
K
E
E
I
P
T
H
S
Y
S
P
E
A
A
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q9CYV5
458
52345
S196
K
E
E
I
P
T
H
S
Y
S
P
E
T
A
Y
Rat
Rattus norvegicus
Q5U4F4
458
52340
S196
K
E
E
I
P
T
H
S
Y
S
P
E
T
A
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512018
482
54954
S220
K
E
E
I
P
T
H
S
Y
S
P
E
A
A
F
Chicken
Gallus gallus
XP_417208
462
52692
I196
F
I
V
G
K
E
E
I
P
T
H
S
F
S
P
Frog
Xenopus laevis
Q6GQ39
453
51938
A196
K
E
E
I
P
A
H
A
L
L
P
E
N
M
Y
Zebra Danio
Brachydanio rerio
NP_001082887
465
52617
S196
K
E
E
I
P
T
H
S
C
L
A
E
H
A
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649803
455
50901
K200
E
E
A
G
P
I
V
K
S
G
P
A
V
P
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_508800
445
50447
N206
N
V
S
E
N
L
I
N
E
K
K
I
P
D
N
Sea Urchin
Strong. purpuratus
XP_788346
818
91850
E556
N
S
E
M
P
A
S
E
Q
E
S
N
Q
D
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.1
95.8
N.A.
91.9
91.4
N.A.
81.1
82.4
79.6
74.6
N.A.
31.8
N.A.
32
24.3
Protein Similarity:
100
99.5
99.3
98.2
N.A.
96
95.6
N.A.
86.3
91.1
89.9
85.1
N.A.
50.4
N.A.
49.5
36.6
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
86.6
0
60
73.3
N.A.
20
N.A.
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
13.3
66.6
73.3
N.A.
26.6
N.A.
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
16
0
8
0
0
8
8
39
62
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
16
0
% D
% Glu:
8
77
77
8
0
8
8
8
8
8
0
70
0
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
24
0
0
0
8
0
8
% F
% Gly:
0
0
0
16
0
0
0
0
0
8
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
70
0
0
0
8
0
8
0
0
% H
% Ile:
0
8
0
70
0
8
8
8
0
0
0
8
0
0
0
% I
% Lys:
70
0
0
0
8
0
0
8
0
8
8
0
0
0
0
% K
% Leu:
0
0
0
0
0
8
0
0
8
16
0
0
0
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
16
0
0
0
8
0
0
8
0
0
0
8
8
0
8
% N
% Pro:
0
0
0
0
85
0
0
0
8
0
70
0
8
8
8
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
8
0
0
0
8
62
8
54
8
8
0
8
0
% S
% Thr:
0
0
0
0
0
62
0
0
0
8
0
0
16
0
8
% T
% Val:
0
8
8
0
0
0
8
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
31
0
0
0
0
0
62
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _