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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM135
All Species:
24.85
Human Site:
T450
Identified Species:
45.56
UniProt:
Q86UB9
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86UB9
NP_075069.2
458
52291
T450
D
P
R
Y
T
T
V
T
P
E
L
P
T
E
F
Chimpanzee
Pan troglodytes
XP_001175336
458
52311
T450
D
P
R
Y
T
T
V
T
P
E
L
P
T
E
F
Rhesus Macaque
Macaca mulatta
XP_001104105
458
52398
T450
D
P
R
Y
T
T
V
T
P
E
L
P
T
E
F
Dog
Lupus familis
XP_848695
458
52312
T450
D
P
R
Y
T
T
V
T
P
E
L
P
I
E
F
Cat
Felis silvestris
Mouse
Mus musculus
Q9CYV5
458
52345
T450
D
P
R
Y
T
V
V
T
P
E
L
P
I
D
F
Rat
Rattus norvegicus
Q5U4F4
458
52340
T450
D
P
R
Y
T
V
V
T
P
E
L
P
I
D
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512018
482
54954
T474
D
P
R
Y
T
T
V
T
P
G
L
P
V
E
L
Chicken
Gallus gallus
XP_417208
462
52692
P454
D
P
R
Y
T
V
V
P
P
E
L
P
L
E
L
Frog
Xenopus laevis
Q6GQ39
453
51938
K445
D
P
R
F
C
I
V
K
P
E
L
P
L
D
F
Zebra Danio
Brachydanio rerio
NP_001082887
465
52617
P457
D
P
R
F
V
L
C
P
V
D
M
D
V
Q
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649803
455
50901
L448
N
I
V
E
K
S
S
L
P
A
Y
S
F
A
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_508800
445
50447
N436
D
P
K
Y
A
M
I
N
P
M
L
Y
M
P
L
Sea Urchin
Strong. purpuratus
XP_788346
818
91850
N811
Y
D
T
R
F
T
P
N
L
Q
A
A
G
L
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.1
95.8
N.A.
91.9
91.4
N.A.
81.1
82.4
79.6
74.6
N.A.
31.8
N.A.
32
24.3
Protein Similarity:
100
99.5
99.3
98.2
N.A.
96
95.6
N.A.
86.3
91.1
89.9
85.1
N.A.
50.4
N.A.
49.5
36.6
P-Site Identity:
100
100
100
93.3
N.A.
80
80
N.A.
80
73.3
60
20
N.A.
6.6
N.A.
33.3
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
80
73.3
73.3
46.6
N.A.
20
N.A.
46.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
8
8
8
0
8
0
% A
% Cys:
0
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
85
8
0
0
0
0
0
0
0
8
0
8
0
24
0
% D
% Glu:
0
0
0
8
0
0
0
0
0
62
0
0
0
47
0
% E
% Phe:
0
0
0
16
8
0
0
0
0
0
0
0
8
0
54
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
8
8
0
0
0
0
0
24
0
0
% I
% Lys:
0
0
8
0
8
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
8
0
8
8
0
77
0
16
8
31
% L
% Met:
0
0
0
0
0
8
0
0
0
8
8
0
8
0
0
% M
% Asn:
8
0
0
0
0
0
0
16
0
0
0
0
0
0
0
% N
% Pro:
0
85
0
0
0
0
8
16
85
0
0
70
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% Q
% Arg:
0
0
77
8
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
8
8
0
0
0
0
8
0
0
8
% S
% Thr:
0
0
8
0
62
47
0
54
0
0
0
0
24
0
0
% T
% Val:
0
0
8
0
8
24
70
0
8
0
0
0
16
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
70
0
0
0
0
0
0
8
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _