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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HOOK3 All Species: 37.58
Human Site: S541 Identified Species: 68.89
UniProt: Q86VS8 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86VS8 NP_115786.1 718 83126 S541 Q G S K A E D S V L L K K K L
Chimpanzee Pan troglodytes XP_001145184 717 83050 S540 Q G S K A E D S V L L K K K L
Rhesus Macaque Macaca mulatta XP_001099564 718 83173 S541 Q G S K A E D S V L L K K K L
Dog Lupus familis XP_532787 718 83205 S541 Q G S K A E D S V L L K K K L
Cat Felis silvestris
Mouse Mus musculus Q8BUK6 718 83199 S541 Q G S K A E D S V L L K K K L
Rat Rattus norvegicus NP_001129570 718 83162 S541 Q G S K A E D S V L L K K K L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509642 837 96168 S660 Q G S K T E D S V L L K K K L
Chicken Gallus gallus Q5ZJ27 718 82961 S537 Q G S K T E G S S N L K Q K L
Frog Xenopus laevis Q6GQ73 719 83201 S538 Q G A K T E D S L L L K K K L
Zebra Danio Brachydanio rerio Q5TZ80 715 83097 S536 Q G A K P D D S H L K R K L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24185 679 76646 A548 K T L Q L E E A V T Q S T S L
Honey Bee Apis mellifera XP_395724 701 81483 I529 G D N K T D N I N L G Q K I T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796541 586 67269 V456 Q V H K L K D V L H K K E D E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 98 98.8 N.A. 97.7 97.9 N.A. 82.8 58.5 89.5 58.2 N.A. 35.9 43.7 N.A. 46.6
Protein Similarity: 100 99 98.6 99.8 N.A. 99.1 99.4 N.A. 85.1 76 95.9 77.3 N.A. 58 67.5 N.A. 61.9
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 66.6 80 46.6 N.A. 20 20 N.A. 26.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 73.3 93.3 66.6 N.A. 46.6 46.6 N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 16 0 47 0 0 8 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 16 77 0 0 0 0 0 0 8 8 % D
% Glu: 0 0 0 0 0 77 8 0 0 0 0 0 8 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 77 0 0 0 0 8 0 0 0 8 0 0 0 0 % G
% His: 0 0 8 0 0 0 0 0 8 8 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 8 0 0 0 0 0 8 0 % I
% Lys: 8 0 0 93 0 8 0 0 0 0 16 77 77 70 0 % K
% Leu: 0 0 8 0 16 0 0 0 16 77 70 0 0 8 77 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 8 0 8 8 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 85 0 0 8 0 0 0 0 0 0 8 8 8 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % R
% Ser: 0 0 62 0 0 0 0 77 8 0 0 8 0 8 0 % S
% Thr: 0 8 0 0 31 0 0 0 0 8 0 0 8 0 8 % T
% Val: 0 8 0 0 0 0 0 8 62 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _