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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC22A16
All Species:
10.91
Human Site:
T74
Identified Species:
21.82
UniProt:
Q86VW1
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86VW1
NP_149116.2
577
64614
T74
S
N
W
S
L
E
D
T
G
A
L
L
S
S
G
Chimpanzee
Pan troglodytes
XP_518688
577
64517
T74
S
N
W
S
L
E
D
T
G
A
L
L
S
S
G
Rhesus Macaque
Macaca mulatta
XP_001088188
576
64507
T74
S
N
W
S
L
E
D
T
G
A
L
L
S
S
G
Dog
Lupus familis
XP_532263
581
65406
I79
S
S
W
R
L
E
D
I
W
I
L
F
F
T
G
Cat
Felis silvestris
Mouse
Mus musculus
Q497L8
649
73915
I74
S
A
W
R
L
E
D
I
L
A
L
R
S
P
E
Rat
Rattus norvegicus
O70594
557
62549
E70
R
N
H
S
I
P
L
E
T
K
D
G
R
Q
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506852
220
25236
Chicken
Gallus gallus
XP_419787
714
78413
D205
S
S
K
A
S
L
E
D
I
W
T
M
W
T
S
Frog
Xenopus laevis
Q66KG0
566
63736
Y78
E
S
W
T
S
K
D
Y
L
V
V
Q
Q
E
N
Zebra Danio
Brachydanio rerio
Q6NYN7
560
61953
L72
V
L
R
A
T
V
P
L
G
L
N
G
K
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95R48
567
63148
E74
N
L
S
Y
P
E
N
E
R
C
S
Y
Y
D
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U539
585
65444
H74
G
N
P
P
H
T
C
H
I
P
E
G
K
E
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
95.6
67.4
N.A.
50.8
30.8
N.A.
27.2
47.9
57.7
27.5
N.A.
34.4
N.A.
27.5
N.A.
Protein Similarity:
100
99.3
96.7
80.9
N.A.
65
51.9
N.A.
32.7
61.9
74.3
47.4
N.A.
55.2
N.A.
46.5
N.A.
P-Site Identity:
100
100
100
46.6
N.A.
53.3
13.3
N.A.
0
6.6
13.3
6.6
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
60
N.A.
53.3
20
N.A.
0
40
40
13.3
N.A.
20
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
17
0
0
0
0
0
34
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
9
0
0
9
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
50
9
0
0
9
0
0
9
0
% D
% Glu:
9
0
0
0
0
50
9
17
0
0
9
0
0
17
17
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
9
9
0
0
% F
% Gly:
9
0
0
0
0
0
0
0
34
0
0
25
0
0
34
% G
% His:
0
0
9
0
9
0
0
9
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
9
0
0
17
17
9
0
0
0
0
0
% I
% Lys:
0
0
9
0
0
9
0
0
0
9
0
0
17
0
0
% K
% Leu:
0
17
0
0
42
9
9
9
17
9
42
25
0
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
9
42
0
0
0
0
9
0
0
0
9
0
0
0
9
% N
% Pro:
0
0
9
9
9
9
9
0
0
9
0
0
0
9
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
9
9
9
0
% Q
% Arg:
9
0
9
17
0
0
0
0
9
0
0
9
9
0
0
% R
% Ser:
50
25
9
34
17
0
0
0
0
0
9
0
34
25
9
% S
% Thr:
0
0
0
9
9
9
0
25
9
0
9
0
0
17
0
% T
% Val:
9
0
0
0
0
9
0
0
0
9
9
0
0
0
17
% V
% Trp:
0
0
50
0
0
0
0
0
9
9
0
0
9
0
0
% W
% Tyr:
0
0
0
9
0
0
0
9
0
0
0
9
9
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _