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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: METT10D All Species: 30.91
Human Site: S254 Identified Species: 48.57
UniProt: Q86W50 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86W50 NP_076991.3 562 63621 S254 C M L G K K C S L A P L K E E
Chimpanzee Pan troglodytes XP_523533 562 63576 S254 C M L G K K C S L A P L K E E
Rhesus Macaque Macaca mulatta XP_001117412 528 60111 C253 S C M L G K K C S L A P L K E
Dog Lupus familis XP_537774 561 63494 S254 C M L G K K C S L A P L K E E
Cat Felis silvestris
Mouse Mus musculus Q9CQG2 553 62322 S254 C M L G K K C S L A P L K E E
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508494 563 63386 S254 C M L G K K C S L A P L K E E
Chicken Gallus gallus Q5ZIA0 558 63368 S254 C M L G K K C S L A P L K E E
Frog Xenopus laevis Q6GR37 547 61864 S254 C M L G K K C S L A P L K E E
Zebra Danio Brachydanio rerio Q6DC64 471 53602 G218 T E I M A E G G E L E F V K R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7K3B9 305 35128 R52 G K V S V N F R N E K T L R E
Honey Bee Apis mellifera XP_624889 356 41810 V103 S F N E M Q E V I G I D I G T
Nematode Worm Caenorhab. elegans Q09357 479 53786 A226 A P H S A T F A S S A E L F V
Sea Urchin Strong. purpuratus XP_793611 657 72899 S256 S M L G K K S S L A L V R E E
Poplar Tree Populus trichocarpa XP_002306173 443 49337 N190 S N C G E S V N C E N K M D G
Maize Zea mays NP_001143191 468 50996 K215 H I L V G V V K E S E S F D F
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 87.9 92.5 N.A. 87.7 N.A. N.A. 79 76.3 70.8 65.3 N.A. 22.9 27.7 31.6 35.1
Protein Similarity: 100 99.8 90.5 95 N.A. 91.9 N.A. N.A. 86.1 84.8 79.1 74.5 N.A. 34.7 43.5 47.1 53.7
P-Site Identity: 100 100 13.3 100 N.A. 100 N.A. N.A. 100 100 100 0 N.A. 6.6 0 0 66.6
P-Site Similarity: 100 100 26.6 100 N.A. 100 N.A. N.A. 100 100 100 20 N.A. 13.3 13.3 13.3 80
Percent
Protein Identity: 23.4 25.4 N.A. N.A. N.A. N.A.
Protein Similarity: 39.1 40.5 N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 26.6 26.6 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 14 0 0 7 0 54 14 0 0 0 0 % A
% Cys: 47 7 7 0 0 0 47 7 7 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 7 0 14 0 % D
% Glu: 0 7 0 7 7 7 7 0 14 14 14 7 0 54 67 % E
% Phe: 0 7 0 0 0 0 14 0 0 0 0 7 7 7 7 % F
% Gly: 7 0 0 60 14 0 7 7 0 7 0 0 0 7 7 % G
% His: 7 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 7 0 0 0 0 0 7 0 7 0 7 0 0 % I
% Lys: 0 7 0 0 54 60 7 7 0 0 7 7 47 14 0 % K
% Leu: 0 0 60 7 0 0 0 0 54 14 7 47 20 0 0 % L
% Met: 0 54 7 7 7 0 0 0 0 0 0 0 7 0 0 % M
% Asn: 0 7 7 0 0 7 0 7 7 0 7 0 0 0 0 % N
% Pro: 0 7 0 0 0 0 0 0 0 0 47 7 0 0 0 % P
% Gln: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 7 0 0 0 0 7 7 7 % R
% Ser: 27 0 0 14 0 7 7 54 14 14 0 7 0 0 0 % S
% Thr: 7 0 0 0 0 7 0 0 0 0 0 7 0 0 7 % T
% Val: 0 0 7 7 7 7 14 7 0 0 0 7 7 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _