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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: METT10D All Species: 33.03
Human Site: S43 Identified Species: 51.9
UniProt: Q86W50 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86W50 NP_076991.3 562 63621 S43 I N L N G R V S L N F K D P E
Chimpanzee Pan troglodytes XP_523533 562 63576 S43 I N L N G R V S L N F K D P E
Rhesus Macaque Macaca mulatta XP_001117412 528 60111 S43 I N L N G R V S L N F K D P E
Dog Lupus familis XP_537774 561 63494 S43 I N L S G R V S L N F K D P E
Cat Felis silvestris
Mouse Mus musculus Q9CQG2 553 62322 S43 I N L N G R V S L N F K D P E
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508494 563 63386 S43 I N L S G R V S L N F K D P E
Chicken Gallus gallus Q5ZIA0 558 63368 S43 T T L A G R V S L N F K D P E
Frog Xenopus laevis Q6GR37 547 61864 S43 V N L A G R V S L N F K D P C
Zebra Danio Brachydanio rerio Q6DC64 471 53602 P17 R N R Y K D K P P D F V Y L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7K3B9 305 35128
Honey Bee Apis mellifera XP_624889 356 41810
Nematode Worm Caenorhab. elegans Q09357 479 53786 V25 P D F K A L A V E Y P E F R K
Sea Urchin Strong. purpuratus XP_793611 657 72899 T43 R N Q A G K A T L D F H D S E
Poplar Tree Populus trichocarpa XP_002306173 443 49337
Maize Zea mays NP_001143191 468 50996 E14 R R R R D G S E T P S M H P R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 87.9 92.5 N.A. 87.7 N.A. N.A. 79 76.3 70.8 65.3 N.A. 22.9 27.7 31.6 35.1
Protein Similarity: 100 99.8 90.5 95 N.A. 91.9 N.A. N.A. 86.1 84.8 79.1 74.5 N.A. 34.7 43.5 47.1 53.7
P-Site Identity: 100 100 100 93.3 N.A. 100 N.A. N.A. 93.3 80 80 13.3 N.A. 0 0 0 40
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. 100 80 86.6 20 N.A. 0 0 20 60
Percent
Protein Identity: 23.4 25.4 N.A. N.A. N.A. N.A.
Protein Similarity: 39.1 40.5 N.A. N.A. N.A. N.A.
P-Site Identity: 0 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 0 6.6 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 20 7 0 14 0 0 0 0 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % C
% Asp: 0 7 0 0 7 7 0 0 0 14 0 0 60 0 0 % D
% Glu: 0 0 0 0 0 0 0 7 7 0 0 7 0 0 54 % E
% Phe: 0 0 7 0 0 0 0 0 0 0 67 0 7 0 0 % F
% Gly: 0 0 0 0 60 7 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 7 7 0 0 % H
% Ile: 40 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 7 7 7 7 0 0 0 0 54 0 0 7 % K
% Leu: 0 0 54 0 0 7 0 0 60 0 0 0 0 7 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % M
% Asn: 0 60 0 27 0 0 0 0 0 54 0 0 0 0 0 % N
% Pro: 7 0 0 0 0 0 0 7 7 7 7 0 0 60 0 % P
% Gln: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 20 7 14 7 0 54 0 0 0 0 0 0 0 7 7 % R
% Ser: 0 0 0 14 0 0 7 54 0 0 7 0 0 7 0 % S
% Thr: 7 7 0 0 0 0 0 7 7 0 0 0 0 0 0 % T
% Val: 7 0 0 0 0 0 54 7 0 0 0 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 7 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _