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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: METT10D All Species: 32.12
Human Site: Y245 Identified Species: 50.48
UniProt: Q86W50 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86W50 NP_076991.3 562 63621 Y245 L K K R L R W Y S C M L G K K
Chimpanzee Pan troglodytes XP_523533 562 63576 Y245 L K K R L R W Y S C M L G K K
Rhesus Macaque Macaca mulatta XP_001117412 528 60111 W244 Q L K K R L R W Y S C M L G K
Dog Lupus familis XP_537774 561 63494 Y245 L K K R L R W Y S C M L G K K
Cat Felis silvestris
Mouse Mus musculus Q9CQG2 553 62322 Y245 L K K R L R W Y S C M L G K K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508494 563 63386 Y245 L K K R L R W Y S C M L G K K
Chicken Gallus gallus Q5ZIA0 558 63368 Y245 L K K R L R W Y S C M L G K K
Frog Xenopus laevis Q6GR37 547 61864 Y245 L K K R L R W Y S C M L G K K
Zebra Danio Brachydanio rerio Q6DC64 471 53602 G209 P S S I N T G G V T E I M A E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7K3B9 305 35128 L43 R Q Q C Q L E L N G K V S V N
Honey Bee Apis mellifera XP_624889 356 41810 Y94 W I E D L M K Y I S F N E M Q
Nematode Worm Caenorhab. elegans Q09357 479 53786 R217 N R V A S E F R T A P H S A T
Sea Urchin Strong. purpuratus XP_793611 657 72899 Y247 L R N Q V V W Y T S M L G K K
Poplar Tree Populus trichocarpa XP_002306173 443 49337 E181 C Q S A I S I E D S N C G E S
Maize Zea mays NP_001143191 468 50996 K206 A E D V A M P K P H I L V G V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 87.9 92.5 N.A. 87.7 N.A. N.A. 79 76.3 70.8 65.3 N.A. 22.9 27.7 31.6 35.1
Protein Similarity: 100 99.8 90.5 95 N.A. 91.9 N.A. N.A. 86.1 84.8 79.1 74.5 N.A. 34.7 43.5 47.1 53.7
P-Site Identity: 100 100 13.3 100 N.A. 100 N.A. N.A. 100 100 100 0 N.A. 0 13.3 0 53.3
P-Site Similarity: 100 100 33.3 100 N.A. 100 N.A. N.A. 100 100 100 13.3 N.A. 26.6 26.6 20 80
Percent
Protein Identity: 23.4 25.4 N.A. N.A. N.A. N.A.
Protein Similarity: 39.1 40.5 N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 26.6 20 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 14 7 0 0 0 0 7 0 0 0 14 0 % A
% Cys: 7 0 0 7 0 0 0 0 0 47 7 7 0 0 0 % C
% Asp: 0 0 7 7 0 0 0 0 7 0 0 0 0 0 0 % D
% Glu: 0 7 7 0 0 7 7 7 0 0 7 0 7 7 7 % E
% Phe: 0 0 0 0 0 0 7 0 0 0 7 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 7 7 0 7 0 0 60 14 0 % G
% His: 0 0 0 0 0 0 0 0 0 7 0 7 0 0 0 % H
% Ile: 0 7 0 7 7 0 7 0 7 0 7 7 0 0 0 % I
% Lys: 0 47 54 7 0 0 7 7 0 0 7 0 0 54 60 % K
% Leu: 54 7 0 0 54 14 0 7 0 0 0 60 7 0 0 % L
% Met: 0 0 0 0 0 14 0 0 0 0 54 7 7 7 0 % M
% Asn: 7 0 7 0 7 0 0 0 7 0 7 7 0 0 7 % N
% Pro: 7 0 0 0 0 0 7 0 7 0 7 0 0 0 0 % P
% Gln: 7 14 7 7 7 0 0 0 0 0 0 0 0 0 7 % Q
% Arg: 7 14 0 47 7 47 7 7 0 0 0 0 0 0 0 % R
% Ser: 0 7 14 0 7 7 0 0 47 27 0 0 14 0 7 % S
% Thr: 0 0 0 0 0 7 0 0 14 7 0 0 0 0 7 % T
% Val: 0 0 7 7 7 7 0 0 7 0 0 7 7 7 7 % V
% Trp: 7 0 0 0 0 0 54 7 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 60 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _