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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LDHD
All Species:
5.45
Human Site:
S225
Identified Species:
13.33
UniProt:
Q86WU2
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86WU2
NP_705690.2
507
54871
S225
P
H
H
T
A
W
Y
S
P
C
V
S
L
G
R
Chimpanzee
Pan troglodytes
XP_511108
507
54880
S225
P
H
H
T
A
W
Y
S
P
C
V
S
L
G
R
Rhesus Macaque
Macaca mulatta
XP_001103000
490
52661
T208
P
D
G
R
L
L
H
T
A
G
Q
G
R
H
F
Dog
Lupus familis
XP_852976
483
51580
A212
G
R
H
F
R
K
S
A
A
G
Y
N
L
T
G
Cat
Felis silvestris
Mouse
Mus musculus
Q7TNG8
484
51829
L229
F
V
G
S
E
G
T
L
G
I
I
T
S
T
T
Rat
Rattus norvegicus
P84850
535
58786
I249
V
V
L
A
D
G
T
I
L
N
C
L
T
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L258
533
58696
V246
V
V
L
A
D
G
H
V
L
N
C
L
A
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796456
478
51611
V221
Y
N
L
T
S
L
F
V
G
S
E
G
T
L
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AX4
567
62157
V279
V
V
L
P
N
G
D
V
V
K
T
A
S
R
A
Baker's Yeast
Sacchar. cerevisiae
P32891
587
65274
L306
A
G
Y
N
L
N
G
L
F
V
G
S
E
G
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
89.5
80.6
N.A.
81.6
25
N.A.
N.A.
N.A.
N.A.
23.6
N.A.
N.A.
N.A.
N.A.
54
Protein Similarity:
100
100
91.7
86.1
N.A.
87.3
40.5
N.A.
N.A.
N.A.
N.A.
41.4
N.A.
N.A.
N.A.
N.A.
69.2
P-Site Identity:
100
100
6.6
13.3
N.A.
0
0
N.A.
N.A.
N.A.
N.A.
0
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
20
26.6
N.A.
20
0
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.8
26.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
45.5
43.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
20
20
0
0
10
20
0
0
10
10
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
20
20
0
0
0
0
% C
% Asp:
0
10
0
0
20
0
10
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
10
0
0
0
0
0
10
0
10
0
0
% E
% Phe:
10
0
0
10
0
0
10
0
10
0
0
0
0
0
10
% F
% Gly:
10
10
20
0
0
40
10
0
20
20
10
20
0
30
20
% G
% His:
0
20
30
0
0
0
20
0
0
0
0
0
0
10
0
% H
% Ile:
0
0
0
0
0
0
0
10
0
10
10
0
0
0
0
% I
% Lys:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% K
% Leu:
0
0
40
0
20
20
0
20
20
0
0
20
30
10
20
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
10
10
10
0
0
0
20
0
10
0
0
0
% N
% Pro:
30
0
0
10
0
0
0
0
20
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% Q
% Arg:
0
10
0
10
10
0
0
0
0
0
0
0
10
10
20
% R
% Ser:
0
0
0
10
10
0
10
20
0
10
0
30
20
10
0
% S
% Thr:
0
0
0
30
0
0
20
10
0
0
10
10
20
30
20
% T
% Val:
30
40
0
0
0
0
0
30
10
10
20
0
0
0
0
% V
% Trp:
0
0
0
0
0
20
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
10
0
0
0
20
0
0
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _