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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LDHD
All Species:
20.3
Human Site:
S412
Identified Species:
49.63
UniProt:
Q86WU2
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86WU2
NP_705690.2
507
54871
S412
T
K
E
D
L
N
A
S
G
L
T
G
S
I
V
Chimpanzee
Pan troglodytes
XP_511108
507
54880
S412
T
K
E
D
L
N
A
S
G
L
T
G
S
I
V
Rhesus Macaque
Macaca mulatta
XP_001103000
490
52661
S395
T
K
E
D
L
N
A
S
G
L
T
G
S
I
V
Dog
Lupus familis
XP_852976
483
51580
S388
T
K
E
D
L
K
A
S
G
L
T
G
T
I
V
Cat
Felis silvestris
Mouse
Mus musculus
Q7TNG8
484
51829
Q418
D
P
D
D
A
E
E
Q
R
R
V
K
A
F
A
Rat
Rattus norvegicus
P84850
535
58786
R439
L
R
T
R
L
G
P
R
A
K
H
V
V
G
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L258
533
58696
M436
M
R
R
H
L
G
G
M
A
K
N
V
V
G
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796456
478
51611
I412
M
D
R
E
G
D
E
I
K
K
A
K
E
F
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AX4
567
62157
S466
S
K
K
E
L
D
A
S
S
L
L
C
T
V
I
Baker's Yeast
Sacchar. cerevisiae
P32891
587
65274
S482
T
K
K
D
M
Q
A
S
K
L
I
N
A
I
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
89.5
80.6
N.A.
81.6
25
N.A.
N.A.
N.A.
N.A.
23.6
N.A.
N.A.
N.A.
N.A.
54
Protein Similarity:
100
100
91.7
86.1
N.A.
87.3
40.5
N.A.
N.A.
N.A.
N.A.
41.4
N.A.
N.A.
N.A.
N.A.
69.2
P-Site Identity:
100
100
100
86.6
N.A.
6.6
6.6
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
93.3
N.A.
20
13.3
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.8
26.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
45.5
43.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
80
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
60
0
20
0
10
0
20
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% C
% Asp:
10
10
10
60
0
20
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
40
20
0
10
20
0
0
0
0
0
10
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
20
0
% F
% Gly:
0
0
0
0
10
20
10
0
40
0
0
40
0
20
0
% G
% His:
0
0
0
10
0
0
0
0
0
0
10
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
10
0
0
10
0
0
50
10
% I
% Lys:
0
60
20
0
0
10
0
0
20
30
0
20
0
0
0
% K
% Leu:
10
0
0
0
70
0
0
0
0
60
10
0
0
0
0
% L
% Met:
20
0
0
0
10
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
30
0
0
0
0
10
10
0
0
0
% N
% Pro:
0
10
0
0
0
0
10
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
10
0
10
0
0
0
0
0
0
0
% Q
% Arg:
0
20
20
10
0
0
0
10
10
10
0
0
0
0
0
% R
% Ser:
10
0
0
0
0
0
0
60
10
0
0
0
30
0
0
% S
% Thr:
50
0
10
0
0
0
0
0
0
0
40
0
20
0
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
10
20
20
10
50
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
20
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _