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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LDHD
All Species:
12.73
Human Site:
Y375
Identified Species:
31.11
UniProt:
Q86WU2
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86WU2
NP_705690.2
507
54871
Y375
T
A
R
H
N
A
W
Y
A
A
L
A
T
R
P
Chimpanzee
Pan troglodytes
XP_511108
507
54880
Y375
T
A
R
H
N
A
W
Y
A
A
L
A
T
R
P
Rhesus Macaque
Macaca mulatta
XP_001103000
490
52661
Y358
T
A
R
H
N
A
W
Y
A
A
L
A
M
R
P
Dog
Lupus familis
XP_852976
483
51580
Y351
A
A
R
H
S
A
W
Y
A
A
L
A
L
R
P
Cat
Felis silvestris
Mouse
Mus musculus
Q7TNG8
484
51829
E381
R
L
P
E
I
L
V
E
T
K
E
E
I
K
A
Rat
Rattus norvegicus
P84850
535
58786
R402
M
L
W
A
L
R
E
R
I
T
E
A
L
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L258
533
58696
R399
A
L
W
S
L
R
E
R
V
T
E
A
L
T
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796456
478
51611
L375
S
E
M
P
R
V
I
L
E
T
I
D
D
L
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AX4
567
62157
W429
K
I
R
K
E
A
L
W
A
C
Y
A
M
A
P
Baker's Yeast
Sacchar. cerevisiae
P32891
587
65274
D445
V
A
L
W
S
V
L
D
A
D
K
S
K
D
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
89.5
80.6
N.A.
81.6
25
N.A.
N.A.
N.A.
N.A.
23.6
N.A.
N.A.
N.A.
N.A.
54
Protein Similarity:
100
100
91.7
86.1
N.A.
87.3
40.5
N.A.
N.A.
N.A.
N.A.
41.4
N.A.
N.A.
N.A.
N.A.
69.2
P-Site Identity:
100
100
93.3
80
N.A.
0
6.6
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
93.3
86.6
N.A.
6.6
6.6
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.8
26.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
45.5
43.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
50
0
10
0
50
0
0
60
40
0
70
0
10
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
10
0
10
10
10
0
% D
% Glu:
0
10
0
10
10
0
20
10
10
0
30
10
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
40
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
0
10
0
0
10
0
10
0
10
0
10
0
10
0
0
% I
% Lys:
10
0
0
10
0
0
0
0
0
10
10
0
10
10
10
% K
% Leu:
0
30
10
0
20
10
20
10
0
0
40
0
30
10
0
% L
% Met:
10
0
10
0
0
0
0
0
0
0
0
0
20
0
0
% M
% Asn:
0
0
0
0
30
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
10
10
0
0
0
0
0
0
0
0
0
0
50
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
10
0
50
0
10
20
0
20
0
0
0
0
0
40
10
% R
% Ser:
10
0
0
10
20
0
0
0
0
0
0
10
0
10
0
% S
% Thr:
30
0
0
0
0
0
0
0
10
30
0
0
20
10
0
% T
% Val:
10
0
0
0
0
20
10
0
10
0
0
0
0
0
0
% V
% Trp:
0
0
20
10
0
0
40
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
40
0
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _