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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NIT1 All Species: 21.52
Human Site: S125 Identified Species: 33.81
UniProt: Q86X76 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86X76 NP_005591.1 327 35896 S125 R E C G L W L S L G G F H E R
Chimpanzee Pan troglodytes XP_001152578 327 35808 S125 R E C G L W L S L G G F H E R
Rhesus Macaque Macaca mulatta XP_001115539 327 35953 S125 R E C G L W L S L G G F H E R
Dog Lupus familis XP_536134 334 36663 S132 R E C G L W L S L G G F H E R
Cat Felis silvestris
Mouse Mus musculus Q8VDK1 323 35677 S121 R E C G I W L S L G G F H E R
Rat Rattus norvegicus Q7TQ94 292 32072 G98 L G G F H E R G Q D W E Q T Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q6INI7 276 30746 G82 E C G I Y L I G G S I P E E D
Zebra Danio Brachydanio rerio Q4VBV9 277 30347 G83 C G I Y L V G G S I P E E D G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O76464 460 52213 S111 K C N K I W I S L G G V H E R
Honey Bee Apis mellifera XP_397291 304 34596 I109 I W L S L G G I H E A L D N N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790158 283 31389 I89 D H K V W L S I G G F H E K D
Poplar Tree Populus trichocarpa XP_002316330 293 31915 W99 L A R E S G I W L S L G G F Q
Maize Zea mays NP_001141322 288 31722 Q94 W L S L G G F Q E K G P D D S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8VYF5 326 36438 E113 R M Q K L A K E L G V V I P V
Baker's Yeast Sacchar. cerevisiae P47016 307 34674 L112 N D R V R N V L L Y I D H E G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 96.6 92.2 N.A. 83.7 76.7 N.A. N.A. N.A. 32.1 31.1 N.A. 34.7 47 N.A. 44.3
Protein Similarity: 100 99.6 99 95.2 N.A. 91.7 83.1 N.A. N.A. N.A. 49.8 49.2 N.A. 45.4 64.8 N.A. 63.6
P-Site Identity: 100 100 100 100 N.A. 93.3 0 N.A. N.A. N.A. 6.6 6.6 N.A. 53.3 6.6 N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 6.6 N.A. N.A. N.A. 13.3 13.3 N.A. 73.3 6.6 N.A. 13.3
Percent
Protein Identity: 43.1 40.3 N.A. 28.7 33.3 N.A.
Protein Similarity: 61.4 56.5 N.A. 44.9 51.6 N.A.
P-Site Identity: 6.6 6.6 N.A. 26.6 20 N.A.
P-Site Similarity: 20 13.3 N.A. 26.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 0 7 0 0 0 0 7 0 0 0 0 % A
% Cys: 7 14 34 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 0 0 0 0 0 0 7 0 7 14 14 14 % D
% Glu: 7 34 0 7 0 7 0 7 7 7 0 14 20 54 0 % E
% Phe: 0 0 0 7 0 0 7 0 0 0 7 34 0 7 0 % F
% Gly: 0 14 14 34 7 20 14 20 14 54 47 7 7 0 14 % G
% His: 0 7 0 0 7 0 0 0 7 0 0 7 47 0 0 % H
% Ile: 7 0 7 7 14 0 20 14 0 7 14 0 7 0 0 % I
% Lys: 7 0 7 14 0 0 7 0 0 7 0 0 0 7 0 % K
% Leu: 14 7 7 7 47 14 34 7 60 0 7 7 0 0 0 % L
% Met: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 7 0 0 7 0 0 0 0 0 0 0 7 7 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 7 14 0 7 0 % P
% Gln: 0 0 7 0 0 0 0 7 7 0 0 0 7 0 14 % Q
% Arg: 40 0 14 0 7 0 7 0 0 0 0 0 0 0 40 % R
% Ser: 0 0 7 7 7 0 7 40 7 14 0 0 0 0 7 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % T
% Val: 0 0 0 14 0 7 7 0 0 0 7 14 0 0 7 % V
% Trp: 7 7 0 0 7 40 0 7 0 0 7 0 0 0 0 % W
% Tyr: 0 0 0 7 7 0 0 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _