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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DHFRL1
All Species:
31.52
Human Site:
Y178
Identified Species:
53.33
UniProt:
Q86XF0
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86XF0
NP_789785.1
187
21620
Y178
Q
E
G
K
H
I
K
Y
K
F
E
V
C
E
K
Chimpanzee
Pan troglodytes
XP_001138276
186
21552
Y178
Q
E
G
K
H
I
K
Y
K
F
E
V
Y
E
N
Rhesus Macaque
Macaca mulatta
XP_001110551
187
21428
Y178
Q
E
E
K
G
I
K
Y
K
F
E
V
Y
E
K
Dog
Lupus familis
XP_851329
191
21936
Y182
Q
E
E
K
G
I
K
Y
K
F
E
V
Y
E
K
Cat
Felis silvestris
Mouse
Mus musculus
P00375
187
21588
Y178
Q
E
E
K
G
I
K
Y
K
F
E
V
Y
E
K
Rat
Rattus norvegicus
Q920D2
187
21620
Y178
Q
E
E
K
G
I
K
Y
K
F
E
V
Y
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512236
463
51638
Y189
Q
E
E
K
G
I
Q
Y
R
F
E
V
Y
E
K
Chicken
Gallus gallus
P00378
189
21631
Y177
Q
E
E
D
G
I
Q
Y
K
F
E
V
Y
Q
K
Frog
Xenopus laevis
NP_001088506
189
21877
Y180
Q
E
E
N
G
V
Q
Y
K
F
E
V
Y
E
K
Zebra Danio
Brachydanio rerio
NP_571850
190
21680
Y180
Q
E
D
N
G
V
Q
Y
L
F
E
V
Y
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P17719
182
20756
E174
E
E
N
G
I
K
F
E
Y
K
I
L
E
K
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q93341
189
21583
L176
E
I
F
E
E
N
G
L
K
F
E
F
C
K
W
Sea Urchin
Strong. purpuratus
XP_780421
189
21372
K181
E
E
K
G
I
Q
Y
K
F
E
I
Y
E
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07807
211
24242
E184
E
F
L
P
P
K
V
E
L
P
E
T
D
C
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.3
92.5
84.8
N.A.
86.6
86.6
N.A.
29.5
68.2
59.2
57.8
N.A.
43.8
N.A.
34.3
50.2
Protein Similarity:
100
97.8
94.1
91
N.A.
93
93
N.A.
34.5
82.5
78.3
72.6
N.A.
62
N.A.
56
66.6
P-Site Identity:
100
86.6
80
80
N.A.
80
80
N.A.
66.6
60
60
46.6
N.A.
6.6
N.A.
26.6
6.6
P-Site Similarity:
100
86.6
80
80
N.A.
80
80
N.A.
80
73.3
73.3
60
N.A.
26.6
N.A.
46.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
48.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
15
8
0
% C
% Asp:
0
0
8
8
0
0
0
0
0
0
0
0
8
0
8
% D
% Glu:
29
86
50
8
8
0
0
15
0
8
86
0
15
65
0
% E
% Phe:
0
8
8
0
0
0
8
0
8
79
0
8
0
0
0
% F
% Gly:
0
0
15
15
58
0
8
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
15
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
8
0
0
15
58
0
0
0
0
15
0
0
0
0
% I
% Lys:
0
0
8
50
0
15
43
8
65
8
0
0
0
15
58
% K
% Leu:
0
0
8
0
0
0
0
8
15
0
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
15
0
8
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
8
8
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
72
0
0
0
0
8
29
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
15
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% T
% Val:
0
0
0
0
0
15
8
0
0
0
0
72
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
8
72
8
0
0
8
65
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _