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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VRK2
All Species:
24.85
Human Site:
S218
Identified Species:
42.05
UniProt:
Q86Y07
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86Y07
NP_001123952.1
508
58141
S218
N
G
T
I
E
F
T
S
L
D
A
H
K
G
V
Chimpanzee
Pan troglodytes
XP_001157703
509
58316
S219
N
G
T
I
E
F
T
S
L
D
A
H
K
G
V
Rhesus Macaque
Macaca mulatta
XP_001112841
506
57805
S218
N
G
T
I
E
F
T
S
L
D
A
H
K
G
V
Dog
Lupus familis
XP_531835
550
62093
S278
N
G
T
I
E
F
T
S
V
D
A
H
K
G
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8BN21
503
58100
S218
N
G
T
I
E
F
T
S
L
D
A
H
K
G
V
Rat
Rattus norvegicus
P97633
325
37477
Q68
S
K
L
Y
K
I
L
Q
G
G
V
G
I
P
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512207
479
54436
Y201
L
V
D
Y
G
L
A
Y
R
Y
C
P
E
G
I
Chicken
Gallus gallus
Q5ZLL1
416
47453
A159
L
A
K
K
Y
R
D
A
R
T
H
Q
H
I
P
Frog
Xenopus laevis
Q5BP74
415
47421
D158
G
L
A
K
K
Y
R
D
A
R
T
H
Q
H
I
Zebra Danio
Brachydanio rerio
Q7ZUS1
425
47752
Y168
R
L
L
D
I
L
E
Y
I
H
D
H
E
Y
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KRY6
599
65975
S233
N
G
T
I
E
Y
T
S
R
D
A
H
L
G
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783182
473
53072
K213
R
K
Y
E
E
F
P
K
K
G
H
N
G
T
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42158
450
50928
R193
L
G
I
E
Q
S
R
R
D
D
L
E
S
L
G
Baker's Yeast
Sacchar. cerevisiae
P29295
494
57322
S210
L
I
Y
F
C
K
G
S
L
P
W
Q
G
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.6
87.5
70.9
N.A.
69.4
21.8
N.A.
41.9
24.7
26.5
40.1
N.A.
30.8
N.A.
N.A.
37.4
Protein Similarity:
100
96.2
91.9
78.3
N.A.
79.9
35.4
N.A.
55.3
39.7
41.3
55.7
N.A.
45.9
N.A.
N.A.
52.7
P-Site Identity:
100
100
100
93.3
N.A.
100
0
N.A.
6.6
0
6.6
13.3
N.A.
80
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
20
6.6
33.3
26.6
N.A.
86.6
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.4
23
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.1
40.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
0
8
8
8
0
43
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
0
8
8
0
0
8
8
8
50
8
0
0
0
0
% D
% Glu:
0
0
0
15
50
0
8
0
0
0
0
8
15
0
0
% E
% Phe:
0
0
0
8
0
43
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
50
0
0
8
0
8
0
8
15
0
8
15
50
8
% G
% His:
0
0
0
0
0
0
0
0
0
8
15
58
8
8
8
% H
% Ile:
0
8
8
43
8
8
0
0
8
0
0
0
8
8
15
% I
% Lys:
0
15
8
15
15
8
0
8
8
0
0
0
36
0
8
% K
% Leu:
29
15
15
0
0
15
8
0
36
0
8
0
8
15
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
43
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
8
0
8
0
8
15
% P
% Gln:
0
0
0
0
8
0
0
8
0
0
0
15
8
0
0
% Q
% Arg:
15
0
0
0
0
8
15
8
22
8
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
8
0
50
0
0
0
0
8
0
0
% S
% Thr:
0
0
43
0
0
0
43
0
0
8
8
0
0
8
0
% T
% Val:
0
8
0
0
0
0
0
0
8
0
8
0
0
0
50
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
15
15
8
15
0
15
0
8
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _