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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VRK2
All Species:
23.03
Human Site:
S274
Identified Species:
38.97
UniProt:
Q86Y07
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86Y07
NP_001123952.1
508
58141
S274
L
L
D
E
L
P
Q
S
V
L
K
W
A
P
S
Chimpanzee
Pan troglodytes
XP_001157703
509
58316
S275
L
L
D
E
L
P
Q
S
V
L
K
W
A
P
S
Rhesus Macaque
Macaca mulatta
XP_001112841
506
57805
S274
L
L
D
E
L
P
Q
S
V
L
K
W
A
P
S
Dog
Lupus familis
XP_531835
550
62093
S332
L
L
D
E
L
P
E
S
V
L
K
W
A
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BN21
503
58100
S274
L
L
D
E
L
P
E
S
V
L
K
W
A
P
S
Rat
Rattus norvegicus
P97633
325
37477
M115
F
T
M
K
T
V
L
M
L
A
D
Q
M
I
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512207
479
54436
C249
D
L
E
I
L
G
Y
C
M
I
Q
W
L
S
G
Chicken
Gallus gallus
Q5ZLL1
416
47453
F206
L
G
Y
V
L
M
Y
F
N
L
G
S
L
P
W
Frog
Xenopus laevis
Q5BP74
415
47421
Y205
S
L
G
Y
V
L
M
Y
F
N
L
G
S
L
P
Zebra Danio
Brachydanio rerio
Q7ZUS1
425
47752
K215
E
G
V
P
K
E
Y
K
E
D
P
K
R
C
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KRY6
599
65975
S290
F
M
D
N
I
G
E
S
L
K
T
L
F
P
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783182
473
53072
T261
L
P
W
E
D
K
L
T
D
L
N
Y
V
M
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42158
450
50928
L240
V
S
T
S
I
E
A
L
C
R
G
Y
P
S
E
Baker's Yeast
Sacchar. cerevisiae
P29295
494
57322
F268
D
E
K
P
D
Y
L
F
L
A
R
L
F
K
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.6
87.5
70.9
N.A.
69.4
21.8
N.A.
41.9
24.7
26.5
40.1
N.A.
30.8
N.A.
N.A.
37.4
Protein Similarity:
100
96.2
91.9
78.3
N.A.
79.9
35.4
N.A.
55.3
39.7
41.3
55.7
N.A.
45.9
N.A.
N.A.
52.7
P-Site Identity:
100
100
100
93.3
N.A.
93.3
6.6
N.A.
20
26.6
6.6
0
N.A.
20
N.A.
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
46.6
26.6
20
0
N.A.
46.6
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.4
23
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.1
40.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
15
0
0
36
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
8
0
0
0
0
8
0
% C
% Asp:
15
0
43
0
15
0
0
0
8
8
8
0
0
0
8
% D
% Glu:
8
8
8
43
0
15
22
0
8
0
0
0
0
0
8
% E
% Phe:
15
0
0
0
0
0
0
15
8
0
0
0
15
0
0
% F
% Gly:
0
15
8
0
0
15
0
0
0
0
15
8
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
8
15
0
0
0
0
8
0
0
0
8
0
% I
% Lys:
0
0
8
8
8
8
0
8
0
8
36
8
0
8
8
% K
% Leu:
50
50
0
0
50
8
22
8
22
50
8
15
15
8
0
% L
% Met:
0
8
8
0
0
8
8
8
8
0
0
0
8
8
0
% M
% Asn:
0
0
0
8
0
0
0
0
8
8
8
0
0
0
8
% N
% Pro:
0
8
0
15
0
36
0
0
0
0
8
0
8
50
8
% P
% Gln:
0
0
0
0
0
0
22
0
0
0
8
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
8
0
8
0
0
% R
% Ser:
8
8
0
8
0
0
0
43
0
0
0
8
8
15
43
% S
% Thr:
0
8
8
0
8
0
0
8
0
0
8
0
0
0
0
% T
% Val:
8
0
8
8
8
8
0
0
36
0
0
0
8
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
43
0
0
8
% W
% Tyr:
0
0
8
8
0
8
22
8
0
0
0
15
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _