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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VRK2 All Species: 23.03
Human Site: S274 Identified Species: 38.97
UniProt: Q86Y07 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86Y07 NP_001123952.1 508 58141 S274 L L D E L P Q S V L K W A P S
Chimpanzee Pan troglodytes XP_001157703 509 58316 S275 L L D E L P Q S V L K W A P S
Rhesus Macaque Macaca mulatta XP_001112841 506 57805 S274 L L D E L P Q S V L K W A P S
Dog Lupus familis XP_531835 550 62093 S332 L L D E L P E S V L K W A P S
Cat Felis silvestris
Mouse Mus musculus Q8BN21 503 58100 S274 L L D E L P E S V L K W A P S
Rat Rattus norvegicus P97633 325 37477 M115 F T M K T V L M L A D Q M I S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512207 479 54436 C249 D L E I L G Y C M I Q W L S G
Chicken Gallus gallus Q5ZLL1 416 47453 F206 L G Y V L M Y F N L G S L P W
Frog Xenopus laevis Q5BP74 415 47421 Y205 S L G Y V L M Y F N L G S L P
Zebra Danio Brachydanio rerio Q7ZUS1 425 47752 K215 E G V P K E Y K E D P K R C H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KRY6 599 65975 S290 F M D N I G E S L K T L F P K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783182 473 53072 T261 L P W E D K L T D L N Y V M N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42158 450 50928 L240 V S T S I E A L C R G Y P S E
Baker's Yeast Sacchar. cerevisiae P29295 494 57322 F268 D E K P D Y L F L A R L F K D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.6 87.5 70.9 N.A. 69.4 21.8 N.A. 41.9 24.7 26.5 40.1 N.A. 30.8 N.A. N.A. 37.4
Protein Similarity: 100 96.2 91.9 78.3 N.A. 79.9 35.4 N.A. 55.3 39.7 41.3 55.7 N.A. 45.9 N.A. N.A. 52.7
P-Site Identity: 100 100 100 93.3 N.A. 93.3 6.6 N.A. 20 26.6 6.6 0 N.A. 20 N.A. N.A. 20
P-Site Similarity: 100 100 100 100 N.A. 100 20 N.A. 46.6 26.6 20 0 N.A. 46.6 N.A. N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. 21.4 23 N.A.
Protein Similarity: N.A. N.A. N.A. 38.1 40.7 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 8 0 0 15 0 0 36 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 8 0 0 0 0 8 0 % C
% Asp: 15 0 43 0 15 0 0 0 8 8 8 0 0 0 8 % D
% Glu: 8 8 8 43 0 15 22 0 8 0 0 0 0 0 8 % E
% Phe: 15 0 0 0 0 0 0 15 8 0 0 0 15 0 0 % F
% Gly: 0 15 8 0 0 15 0 0 0 0 15 8 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 0 0 0 8 15 0 0 0 0 8 0 0 0 8 0 % I
% Lys: 0 0 8 8 8 8 0 8 0 8 36 8 0 8 8 % K
% Leu: 50 50 0 0 50 8 22 8 22 50 8 15 15 8 0 % L
% Met: 0 8 8 0 0 8 8 8 8 0 0 0 8 8 0 % M
% Asn: 0 0 0 8 0 0 0 0 8 8 8 0 0 0 8 % N
% Pro: 0 8 0 15 0 36 0 0 0 0 8 0 8 50 8 % P
% Gln: 0 0 0 0 0 0 22 0 0 0 8 8 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 8 8 0 8 0 0 % R
% Ser: 8 8 0 8 0 0 0 43 0 0 0 8 8 15 43 % S
% Thr: 0 8 8 0 8 0 0 8 0 0 8 0 0 0 0 % T
% Val: 8 0 8 8 8 8 0 0 36 0 0 0 8 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 43 0 0 8 % W
% Tyr: 0 0 8 8 0 8 22 8 0 0 0 15 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _