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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VRK2 All Species: 12.12
Human Site: S421 Identified Species: 20.51
UniProt: Q86Y07 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86Y07 NP_001123952.1 508 58141 S421 N S F P Q K I S Y T Q F P N S
Chimpanzee Pan troglodytes XP_001157703 509 58316 S422 N S F P Q K I S Y T Q F P S S
Rhesus Macaque Macaca mulatta XP_001112841 506 57805 N421 N S F P Q K F N Y R Q F P N S
Dog Lupus familis XP_531835 550 62093 S474 E S L N E I K S S S Q Q A S S
Cat Felis silvestris
Mouse Mus musculus Q8BN21 503 58100 S416 Q S L Q Q T P S Y M S F Q G S
Rat Rattus norvegicus P97633 325 37477 C249 S T P V E V L C K G F P A E F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512207 479 54436 S400 Y A R D F D I S L P V Y P L P
Chicken Gallus gallus Q5ZLL1 416 47453 R340 P A G A T G N R L R N V A E P
Frog Xenopus laevis Q5BP74 415 47421 E339 G R L R G T Q E V T P S T P L
Zebra Danio Brachydanio rerio Q7ZUS1 425 47752 T349 F G V A T N S T S L P S V K T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KRY6 599 65975 S487 I N F S P S I S L R G R P G G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783182 473 53072 A396 P K K R T A S A K E P V K S P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42158 450 50928 L374 S M I P S S S L F A Q S A G S
Baker's Yeast Sacchar. cerevisiae P29295 494 57322 P418 P Q Q L Q Q Q P N G Q R P N Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.6 87.5 70.9 N.A. 69.4 21.8 N.A. 41.9 24.7 26.5 40.1 N.A. 30.8 N.A. N.A. 37.4
Protein Similarity: 100 96.2 91.9 78.3 N.A. 79.9 35.4 N.A. 55.3 39.7 41.3 55.7 N.A. 45.9 N.A. N.A. 52.7
P-Site Identity: 100 93.3 80 26.6 N.A. 40 0 N.A. 20 0 6.6 0 N.A. 26.6 N.A. N.A. 0
P-Site Similarity: 100 100 86.6 46.6 N.A. 40 26.6 N.A. 33.3 6.6 6.6 13.3 N.A. 33.3 N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 21.4 23 N.A.
Protein Similarity: N.A. N.A. N.A. 38.1 40.7 N.A.
P-Site Identity: N.A. N.A. N.A. 20 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 0 15 0 8 0 8 0 8 0 0 29 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 8 0 0 0 0 0 0 0 0 0 % D
% Glu: 8 0 0 0 15 0 0 8 0 8 0 0 0 15 0 % E
% Phe: 8 0 29 0 8 0 8 0 8 0 8 29 0 0 8 % F
% Gly: 8 8 8 0 8 8 0 0 0 15 8 0 0 22 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 8 0 0 8 29 0 0 0 0 0 0 0 0 % I
% Lys: 0 8 8 0 0 22 8 0 15 0 0 0 8 8 0 % K
% Leu: 0 0 22 8 0 0 8 8 22 8 0 0 0 8 8 % L
% Met: 0 8 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 22 8 0 8 0 8 8 8 8 0 8 0 0 22 0 % N
% Pro: 22 0 8 29 8 0 8 8 0 8 22 8 43 8 22 % P
% Gln: 8 8 8 8 36 8 15 0 0 0 43 8 8 0 0 % Q
% Arg: 0 8 8 15 0 0 0 8 0 22 0 15 0 0 0 % R
% Ser: 15 36 0 8 8 15 22 43 15 8 8 22 0 22 43 % S
% Thr: 0 8 0 0 22 15 0 8 0 22 0 0 8 0 8 % T
% Val: 0 0 8 8 0 8 0 0 8 0 8 15 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 29 0 0 8 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _