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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VRK2
All Species:
6.67
Human Site:
S475
Identified Species:
11.28
UniProt:
Q86Y07
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86Y07
NP_001123952.1
508
58141
S475
T
G
L
W
P
T
I
S
Q
F
T
L
S
E
E
Chimpanzee
Pan troglodytes
XP_001157703
509
58316
S476
T
G
L
W
P
T
I
S
Q
F
T
L
S
E
E
Rhesus Macaque
Macaca mulatta
XP_001112841
506
57805
F475
L
W
P
T
I
S
Q
F
T
L
S
E
E
T
N
Dog
Lupus familis
XP_531835
550
62093
D528
L
S
E
E
T
K
A
D
M
Y
Y
Y
G
F
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8BN21
503
58100
F470
P
R
F
W
P
A
I
F
Q
L
T
L
S
E
E
Rat
Rattus norvegicus
P97633
325
37477
Q303
F
D
W
T
M
L
K
Q
K
A
A
Q
Q
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512207
479
54436
L454
V
V
D
L
K
S
D
L
S
F
E
K
L
E
E
Chicken
Gallus gallus
Q5ZLL1
416
47453
T394
N
V
S
S
S
D
L
T
G
R
Q
E
V
S
R
Frog
Xenopus laevis
Q5BP74
415
47421
S393
L
T
S
R
Q
D
T
S
R
M
S
T
S
Q
I
Zebra Danio
Brachydanio rerio
Q7ZUS1
425
47752
K403
S
P
A
K
R
P
V
K
K
E
T
Q
A
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KRY6
599
65975
A541
K
K
A
D
Q
D
K
A
T
A
V
D
S
R
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783182
473
53072
P450
I
R
K
I
K
T
K
P
S
Q
M
V
A
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42158
450
50928
R428
G
E
A
G
K
S
T
R
R
H
Y
E
S
V
V
Baker's Yeast
Sacchar. cerevisiae
P29295
494
57322
P472
N
T
N
Q
A
S
V
P
P
Q
M
R
S
N
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.6
87.5
70.9
N.A.
69.4
21.8
N.A.
41.9
24.7
26.5
40.1
N.A.
30.8
N.A.
N.A.
37.4
Protein Similarity:
100
96.2
91.9
78.3
N.A.
79.9
35.4
N.A.
55.3
39.7
41.3
55.7
N.A.
45.9
N.A.
N.A.
52.7
P-Site Identity:
100
100
0
0
N.A.
60
0
N.A.
20
0
13.3
6.6
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
100
13.3
6.6
N.A.
60
6.6
N.A.
26.6
13.3
33.3
33.3
N.A.
13.3
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.4
23
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.1
40.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
22
0
8
8
8
8
0
15
8
0
15
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
8
8
0
22
8
8
0
0
0
8
0
0
0
% D
% Glu:
0
8
8
8
0
0
0
0
0
8
8
22
8
29
29
% E
% Phe:
8
0
8
0
0
0
0
15
0
22
0
0
0
8
0
% F
% Gly:
8
15
0
8
0
0
0
0
8
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
8
0
0
8
8
0
22
0
0
0
0
0
0
0
15
% I
% Lys:
8
8
8
8
22
8
22
8
15
0
0
8
0
0
0
% K
% Leu:
22
0
15
8
0
8
8
8
0
15
0
22
8
0
0
% L
% Met:
0
0
0
0
8
0
0
0
8
8
15
0
0
0
0
% M
% Asn:
15
0
8
0
0
0
0
0
0
0
0
0
0
8
8
% N
% Pro:
8
8
8
0
22
8
0
15
8
0
0
0
0
0
8
% P
% Gln:
0
0
0
8
15
0
8
8
22
15
8
15
8
8
0
% Q
% Arg:
0
15
0
8
8
0
0
8
15
8
0
8
0
8
8
% R
% Ser:
8
8
15
8
8
29
0
22
15
0
15
0
50
22
15
% S
% Thr:
15
15
0
15
8
22
15
8
15
0
29
8
0
8
8
% T
% Val:
8
15
0
0
0
0
15
0
0
0
8
8
8
8
8
% V
% Trp:
0
8
8
22
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
15
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _