Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VRK2 All Species: 8.79
Human Site: T375 Identified Species: 14.87
UniProt: Q86Y07 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86Y07 NP_001123952.1 508 58141 T375 R S A E S C A T W K V Q K E E
Chimpanzee Pan troglodytes XP_001157703 509 58316 T376 R S A E S C A T W K V Q K E E
Rhesus Macaque Macaca mulatta XP_001112841 506 57805 K375 K K E E G C L K G G S L K V E
Dog Lupus familis XP_531835 550 62093 T433 R S A E S C L T G R K V Q K E
Cat Felis silvestris
Mouse Mus musculus Q8BN21 503 58100 E374 T R A R Q R E E Q E D S Q P T
Rat Rattus norvegicus P97633 325 37477 Y209 D D M E S L G Y V L M Y F N R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512207 479 54436 L358 K P G P K E M L F E L R R P A
Chicken Gallus gallus Q5ZLL1 416 47453 N300 L K F G A A R N P E D M D R E
Frog Xenopus laevis Q5BP74 415 47421 R299 M L K F G A S R A A E D A E R
Zebra Danio Brachydanio rerio Q7ZUS1 425 47752 V309 K F M Q E V K V L G Y T D R P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KRY6 599 65975 L421 R N A K V S P L K R V A D S S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783182 473 53072 R355 S P V Q S K K R K A T S K E R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42158 450 50928 G334 R Y T G E E E G R P H M E S S
Baker's Yeast Sacchar. cerevisiae P29295 494 57322 A375 T I L N N N A A S S L P E E L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.6 87.5 70.9 N.A. 69.4 21.8 N.A. 41.9 24.7 26.5 40.1 N.A. 30.8 N.A. N.A. 37.4
Protein Similarity: 100 96.2 91.9 78.3 N.A. 79.9 35.4 N.A. 55.3 39.7 41.3 55.7 N.A. 45.9 N.A. N.A. 52.7
P-Site Identity: 100 100 26.6 53.3 N.A. 6.6 13.3 N.A. 0 6.6 6.6 0 N.A. 20 N.A. N.A. 20
P-Site Similarity: 100 100 33.3 73.3 N.A. 20 20 N.A. 40 20 13.3 13.3 N.A. 40 N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 21.4 23 N.A.
Protein Similarity: N.A. N.A. N.A. 38.1 40.7 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 36 0 8 15 22 8 8 15 0 8 8 0 8 % A
% Cys: 0 0 0 0 0 29 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 8 0 0 0 0 0 0 0 0 15 8 22 0 0 % D
% Glu: 0 0 8 36 15 15 15 8 0 22 8 0 15 36 36 % E
% Phe: 0 8 8 8 0 0 0 0 8 0 0 0 8 0 0 % F
% Gly: 0 0 8 15 15 0 8 8 15 15 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 22 15 8 8 8 8 15 8 15 15 8 0 29 8 0 % K
% Leu: 8 8 8 0 0 8 15 15 8 8 15 8 0 0 8 % L
% Met: 8 0 15 0 0 0 8 0 0 0 8 15 0 0 0 % M
% Asn: 0 8 0 8 8 8 0 8 0 0 0 0 0 8 0 % N
% Pro: 0 15 0 8 0 0 8 0 8 8 0 8 0 15 8 % P
% Gln: 0 0 0 15 8 0 0 0 8 0 0 15 15 0 0 % Q
% Arg: 36 8 0 8 0 8 8 15 8 15 0 8 8 15 22 % R
% Ser: 8 22 0 0 36 8 8 0 8 8 8 15 0 15 15 % S
% Thr: 15 0 8 0 0 0 0 22 0 0 8 8 0 0 8 % T
% Val: 0 0 8 0 8 8 0 8 8 0 22 8 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 15 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 8 0 0 8 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _