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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VRK2
All Species:
13.64
Human Site:
Y176
Identified Species:
23.08
UniProt:
Q86Y07
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86Y07
NP_001123952.1
508
58141
Y176
A
A
N
L
L
L
G
Y
K
N
P
D
Q
V
Y
Chimpanzee
Pan troglodytes
XP_001157703
509
58316
Y177
A
A
N
L
L
L
G
Y
K
N
P
D
Q
V
Y
Rhesus Macaque
Macaca mulatta
XP_001112841
506
57805
Y176
A
A
N
L
L
L
G
Y
K
N
P
D
R
V
Y
Dog
Lupus familis
XP_531835
550
62093
Y236
A
A
N
L
L
L
G
Y
R
N
P
D
R
V
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8BN21
503
58100
F176
A
A
N
L
L
L
D
F
T
N
P
D
R
V
Y
Rat
Rattus norvegicus
P97633
325
37477
G26
L
V
R
K
I
G
S
G
S
F
G
D
I
Y
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512207
479
54436
R159
T
V
L
Q
L
S
L
R
I
L
D
I
L
E
Y
Chicken
Gallus gallus
Q5ZLL1
416
47453
E117
D
Q
M
I
S
R
I
E
Y
I
H
S
K
N
F
Frog
Xenopus laevis
Q5BP74
415
47421
I116
A
D
Q
M
I
S
R
I
E
Y
I
H
S
K
N
Zebra Danio
Brachydanio rerio
Q7ZUS1
425
47752
R126
F
H
E
K
N
G
K
R
Y
R
F
M
V
M
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KRY6
599
65975
L191
L
K
A
A
N
I
L
L
G
L
E
K
G
G
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783182
473
53072
I171
M
N
Y
V
H
A
D
I
K
S
A
N
L
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P42158
450
50928
G151
Q
V
Y
I
I
D
F
G
L
A
K
K
Y
R
D
Baker's Yeast
Sacchar. cerevisiae
P29295
494
57322
R168
T
H
R
H
I
P
Y
R
E
N
K
S
L
T
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.6
87.5
70.9
N.A.
69.4
21.8
N.A.
41.9
24.7
26.5
40.1
N.A.
30.8
N.A.
N.A.
37.4
Protein Similarity:
100
96.2
91.9
78.3
N.A.
79.9
35.4
N.A.
55.3
39.7
41.3
55.7
N.A.
45.9
N.A.
N.A.
52.7
P-Site Identity:
100
100
93.3
86.6
N.A.
73.3
6.6
N.A.
13.3
0
6.6
0
N.A.
0
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
86.6
13.3
N.A.
13.3
20
26.6
6.6
N.A.
6.6
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.4
23
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.1
40.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
43
36
8
8
0
8
0
0
0
8
8
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
0
0
8
15
0
0
0
8
43
0
0
15
% D
% Glu:
0
0
8
0
0
0
0
8
15
0
8
0
0
8
0
% E
% Phe:
8
0
0
0
0
0
8
8
0
8
8
0
0
0
8
% F
% Gly:
0
0
0
0
0
15
29
15
8
0
8
0
8
8
8
% G
% His:
0
15
0
8
8
0
0
0
0
0
8
8
0
0
0
% H
% Ile:
0
0
0
15
29
8
8
15
8
8
8
8
8
0
0
% I
% Lys:
0
8
0
15
0
0
8
0
29
0
15
15
8
8
0
% K
% Leu:
15
0
8
36
43
36
15
8
8
15
0
0
22
8
15
% L
% Met:
8
0
8
8
0
0
0
0
0
0
0
8
0
8
0
% M
% Asn:
0
8
36
0
15
0
0
0
0
43
0
8
0
8
8
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
36
0
0
0
0
% P
% Gln:
8
8
8
8
0
0
0
0
0
0
0
0
15
0
0
% Q
% Arg:
0
0
15
0
0
8
8
22
8
8
0
0
22
8
0
% R
% Ser:
0
0
0
0
8
15
8
0
8
8
0
15
8
0
0
% S
% Thr:
15
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% T
% Val:
0
22
0
8
0
0
0
0
0
0
0
0
8
36
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
15
0
0
0
8
29
15
8
0
0
8
8
43
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _