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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VRK2 All Species: 18.18
Human Site: Y77 Identified Species: 30.77
UniProt: Q86Y07 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86Y07 NP_001123952.1 508 58141 Y77 L F S E L K F Y Q R V A K K D
Chimpanzee Pan troglodytes XP_001157703 509 58316 Y77 L L C I T R M Y M L V Y S E C
Rhesus Macaque Macaca mulatta XP_001112841 506 57805 Y77 L F S E L K F Y Q R V A K K D
Dog Lupus familis XP_531835 550 62093 Y137 L F S E L K F Y Q R A A K K D
Cat Felis silvestris
Mouse Mus musculus Q8BN21 503 58100 Y77 L F S E L K F Y Q R A A K R E
Rat Rattus norvegicus P97633 325 37477
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512207 479 54436 D64 S S K S V G S D A P C V V K V
Chicken Gallus gallus Q5ZLL1 416 47453 Y24 S G S F G D I Y L G A N I A T
Frog Xenopus laevis Q5BP74 415 47421 I23 G S G S F G D I Y L G T D I A
Zebra Danio Brachydanio rerio Q7ZUS1 425 47752 N33 S G E V L T D N A K K K W K L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KRY6 599 65975 Y93 L F V E M H F Y L R N A K L E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783182 473 53072 H78 G P L Y T E L H F Y Q R A A Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42158 450 50928 I58 Y E S K L Y R I L Q G G T G V
Baker's Yeast Sacchar. cerevisiae P29295 494 57322 F71 G I P F I R W F G R E G E Y N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.6 87.5 70.9 N.A. 69.4 21.8 N.A. 41.9 24.7 26.5 40.1 N.A. 30.8 N.A. N.A. 37.4
Protein Similarity: 100 96.2 91.9 78.3 N.A. 79.9 35.4 N.A. 55.3 39.7 41.3 55.7 N.A. 45.9 N.A. N.A. 52.7
P-Site Identity: 100 20 100 93.3 N.A. 80 0 N.A. 6.6 13.3 0 13.3 N.A. 53.3 N.A. N.A. 0
P-Site Similarity: 100 33.3 100 93.3 N.A. 93.3 0 N.A. 13.3 13.3 0 20 N.A. 66.6 N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 21.4 23 N.A.
Protein Similarity: N.A. N.A. N.A. 38.1 40.7 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 15 0 22 36 8 15 8 % A
% Cys: 0 0 8 0 0 0 0 0 0 0 8 0 0 0 8 % C
% Asp: 0 0 0 0 0 8 15 8 0 0 0 0 8 0 22 % D
% Glu: 0 8 8 36 0 8 0 0 0 0 8 0 8 8 15 % E
% Phe: 0 36 0 15 8 0 36 8 8 0 0 0 0 0 0 % F
% Gly: 22 15 8 0 8 15 0 0 8 8 15 15 0 8 0 % G
% His: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 8 8 0 8 15 0 0 0 0 8 8 0 % I
% Lys: 0 0 8 8 0 29 0 0 0 8 8 8 36 36 0 % K
% Leu: 43 8 8 0 43 0 8 0 22 15 0 0 0 8 8 % L
% Met: 0 0 0 0 8 0 8 0 8 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 8 0 0 8 8 0 0 8 % N
% Pro: 0 8 8 0 0 0 0 0 0 8 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 29 8 8 0 0 0 8 % Q
% Arg: 0 0 0 0 0 15 8 0 0 43 0 8 0 8 0 % R
% Ser: 22 15 43 15 0 0 8 0 0 0 0 0 8 0 0 % S
% Thr: 0 0 0 0 15 8 0 0 0 0 0 8 8 0 8 % T
% Val: 0 0 8 8 8 0 0 0 0 0 22 8 8 0 15 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 8 0 0 % W
% Tyr: 8 0 0 8 0 8 0 50 8 8 0 8 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _