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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED12L
All Species:
21.82
Human Site:
S720
Identified Species:
53.33
UniProt:
Q86YW9
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86YW9
NP_443728.3
2145
240120
S720
I
P
L
D
E
S
S
S
H
E
C
N
Q
R
T
Chimpanzee
Pan troglodytes
Q7YQK8
2027
226320
K661
L
G
G
E
D
G
Q
K
R
R
R
N
R
P
E
Rhesus Macaque
Macaca mulatta
XP_001107022
2145
239809
S720
I
P
L
D
E
S
S
S
H
E
C
N
Q
R
T
Dog
Lupus familis
XP_857160
2157
240859
S721
I
P
Q
E
E
S
C
S
H
E
C
N
Q
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BQM9
2157
241407
S720
I
P
L
D
E
S
S
S
H
E
C
N
Q
R
T
Rat
Rattus norvegicus
XP_002727625
2181
243366
S748
I
P
Q
E
E
S
C
S
H
E
C
N
Q
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422838
1480
164510
I195
A
L
N
I
N
G
L
I
D
F
A
I
Q
L
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q2QCI8
2173
243973
S746
I
P
Q
E
E
S
A
S
H
E
C
N
Q
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VW47
2531
279480
M842
I
P
Q
D
D
P
S
M
S
S
Y
S
S
E
S
Honey Bee
Apis mellifera
XP_392792
2190
244564
S718
L
D
S
K
I
P
S
S
H
S
R
H
L
L
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
55.7
98
60.5
N.A.
94.6
59.9
N.A.
N.A.
55.2
N.A.
60.9
N.A.
34.8
42.6
N.A.
N.A.
Protein Similarity:
100
68.7
98.5
74.2
N.A.
96.4
73.7
N.A.
N.A.
59.4
N.A.
74
N.A.
49.9
59.6
N.A.
N.A.
P-Site Identity:
100
6.6
100
73.3
N.A.
100
73.3
N.A.
N.A.
6.6
N.A.
73.3
N.A.
26.6
20
N.A.
N.A.
P-Site Similarity:
100
33.3
100
80
N.A.
100
80
N.A.
N.A.
6.6
N.A.
86.6
N.A.
46.6
33.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
10
0
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
20
0
0
0
60
0
0
0
0
% C
% Asp:
0
10
0
40
20
0
0
0
10
0
0
0
0
0
0
% D
% Glu:
0
0
0
40
60
0
0
0
0
60
0
0
0
10
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
10
10
0
0
20
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
70
0
0
10
0
0
0
% H
% Ile:
70
0
0
10
10
0
0
10
0
0
0
10
0
0
0
% I
% Lys:
0
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% K
% Leu:
20
10
30
0
0
0
10
0
0
0
0
0
10
20
40
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
10
0
0
0
0
0
0
70
0
0
0
% N
% Pro:
0
70
0
0
0
20
0
0
0
0
0
0
0
10
0
% P
% Gln:
0
0
40
0
0
0
10
0
0
0
0
0
70
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
10
10
20
0
10
60
0
% R
% Ser:
0
0
10
0
0
60
50
70
10
20
0
10
10
0
10
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
30
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _